P53蛋白在乳腺癌中表达的META分析  

Correlation of P53 Protein Expression in Breast Cancer:A Meta-analysis

作　　者：周志伟[1] 刘继勇[1] 银广悦[1] 王凌凌[2] 尹志辉 ZHOU Zhiwei;LIU Jiyong;YIN Guangyue;WANG Lingling;YIN Zhihui(Department of Clincal Laboratory,the Center of China National Petroleum Corportion Hebei Langfang 065000,China;Department of Oncology,the Center of China National Petroleum Corportion Hebei Langfang 065000,China;Department of Clincal Laboratory,the Xingtai Third Hospital,Hebei 065000,China)

机构地区：[1]中国石油天然气集团公司中心医院检验科,河北廊坊065000 [2]中国石油天然气集团公司中心医院肿瘤科,河北廊坊065000 [3]河北省邢台市第三医院检验科,河北邢台054000

出　　处：《国际检验医学杂志》2019年第A01期26-28,共3页International Journal of Laboratory Medicine

基　　金：廊坊市科技支撑项目计划(2016013025)。

摘　　要：目的评价P53蛋白表达与乳腺癌发生的相关性。方法计算机检索中国知网、万方、维普数据库在国内公开发表的关于乳腺癌组织中P53表达的病例-对照研究,以此作为基础文献,数据以Revman5.3和R3.4.1软件进行meta分析。结果共搜集到符合要求的文献16篇,Meta分析结果显示,乳腺癌患者P53蛋白阳性率高于乳腺良性病变和正常组织(P<0.05),淋巴结转移组高于淋巴结未转移组(P<0.05),Begg法和Egger法证实文献无明显发表偏倚。结论P53蛋白在乳腺癌患者中的阳性率高于乳腺良性病变和正常组织,淋巴结转移组阳性率高于未转移组。Objective To review the correlation between the expression of P53 and Breast Cancer.Methods all related case-control studies about the association between Breast Cancer and P53 were searched from CNKI and VIP and WANFANG database.data were analyzed by RevMan5.3 and R3.4.1 software.Results 16 studies are included in this article that meeting the criterion we designed.Meta-analysis show that P53 in Breast Cancer group is higher than that in benign breast diseases and normal breast tissues group( P <0.05),the lymphatic metastasis group is higher than non-lymphatic metastasis group,Begg method and Egger method show no bias.Conclusion P53 in Breast Cancer group is higher than that in benign breast diseases and normal breast tissues group( P <0.05),the lymphatic metastasis group is higher than non-lymphatic metastasis group.

关 键 词：乳腺癌 P53蛋白 META分析 

分 类 号：R735.34[医药卫生—肿瘤]