代谢异常指标聚集性与高血压儿童青少年非酒精性脂肪肝的关系  

Association of clustering of metabolic abnormalities with non-alcoholic fatty liver disease in hypertensive children and adolescents

作　　者：张云飞 杨丽丽[1,2] 席波 赵敏[2,3] ZHANG Yunfei;YANG Lili;XI Bo;ZHAO Min(Department of Epidemiology, School of Public Health, Shandong University,Jinan (250012), China)

机构地区：[1]山东大学公共卫生学院流行病学系,济南250012 [2]山东大学儿童心血管研究中心 [3]山东大学公共卫生学院营养学系

出　　处：《中国学校卫生》2019年第6期809-811,共3页Chinese Journal of School Health

基　　金：国家自然科学基金青年项目(81803261);国家科技支撑计划项目(2012BAI03B03)

摘　　要：目的探讨代谢异常指标聚集性与高血压儿童青少年非酒精性脂肪肝(NAFLD)之间的关系,为儿童青少年NAFLD的预防和控制提供科学依据。方法数据来源于2012年9月-2014年9月开展的以学校为基础的横断面研究,共纳入济南市261名6~17岁高血压中小学生。采用趋势χ^2检验分析NAFLD检出率随代谢异常数量增加的变化趋势;控制潜在的混杂变量后,采用多元Logistic回归模型分析高血压儿童青少年代谢异常聚集性对NAFLD的影响。结果在高血压儿童青少年中,携带≤1,2,≥3个代谢异常指标的NAFLD检出率分别为5.3%,25.5%和36.0%。控制性别、年龄和血压等因素后,携带2和≥3个代谢异常指标组罹患NAFLD的风险是携带≤1个代谢异常指标组的6.51(95%CI=2.52~16.81)和8.89倍(95%CI=3.03~26.06)。结论代谢异常指标聚集性可能会增加高血压儿童青少年NAFLD的罹患风险。综合防控各种代谢指标的异常,可能有助于预防和控制高血压儿童青少年的NAFLD。Objective To examine the relationship between clustering of metabolic abnormalities with non-alcoholic fatty liver disease(NAFLD) in hypertensive children and adolescents, and to provide a scientific reference for the prevention and control of NAFLD among children and adolescents. Methods Data were based on a school-based cross-sectional study conducted from September 2012 to September 2014 in Jinan. A total of 261 hypertensive children and adolescents aged 6 to 17 years were included in this study. Chi-square test was used to analyze the prevalence of NAFLD by numbers of metabolic abnormalities. Multivariable logistic regression model was used to examine the relationship between clustering of metabolic abnormalities and NAFLD in hypertensive children and adolescents after adjustment for potential confounding variables. Results Among the included 261 hypertensive participants, the prevalence of NAFLD with the number of metabolic abnormalities ≤1, 2 and ≥3 was 5.3%, 25.5% and 36.0%, respectively. After adjustment for sex, age and systolic/diastolic blood pressure, compared with hypertensive children and adolescents carrying ≤1 metabolic disorder, those with two metabolic disorders had 6.51(95%CI=2.52-16.81) times higher risk for NAFLD, and those with≥3 metabolic disorders had 8.89(95%CI=3.03-26.06) times higher risk. Conclusion Clustering of metabolic abnormalities is an independent risk factor for NAFLD in hypertensive youth. Comprehensive prevention and control of metabolic disorders in childhood may be helpful to prevent NAFLD.

关 键 词：代谢疾病 高血压 脂肪肝 儿童 青少年 

分 类 号：R575.5[医药卫生—消化系统] R179[医药卫生—内科学]