阿帕替尼联合立体定向体部放疗治疗晚期胰腺癌的疗效观察  

Effect of Apatinib Combined with Stereotactic Body Radiotherapy on Short-term Efficacy,Quality of Life and Long-term Efficacy in Patients with Advanced Pancreatic Cancer

作　　者：魏成明[1] 晏军[1] 赵雪峰 邱洪波[1] WEI Chengming;YAN Jun;ZHAO Xuefeng(Zigong First People's Hospital,Zigong,643000)

机构地区：[1]四川省自贡市第一人民医院

出　　处：《实用癌症杂志》2019年第7期1208-1211,共4页The Practical Journal of Cancer

摘　　要：目的探讨阿帕替尼联合立体定向体部放疗对晚期胰腺癌患者近期疗效、生活质量及远期疗效的影响。方法将62例晚期胰腺癌患者随机分为观察组和对照组,每组31例。对照组均给予立体定向体部放疗,观察组在对照组的基础上另给予阿帕替尼。治疗后,观察2组患者临床疗效。治疗前后,分别对2组患者的生活质量进行评价,主要评价指标包括情绪功能、社会功能、躯体功能及认知功能。治疗后,对患者进行为期2年的随访,观察患者1年生存率、2年生存率、无疾病进展生存时间(PFS)和总生存时间(OS)。治疗期间,密切观察2组患者出现的毒副作用,主要观察项目包括白细胞降低、恶心呕吐、放射性肠炎、放射性皮炎、肝肾功能异常及血小板降低等。结果治疗后,观察组CBR及ORR均明显高于对照组(P <0. 05)。治疗后,观察组情绪功能、社会功能、躯体功能及认知功能评分均明显高于对照组(P <0. 05)。治疗后,观察组1年生存率、2年生存率、PFS及OS均显著高于对照组(P <0. 05)。治疗期间,2组患者白细胞降低、恶心呕吐、放射性肠炎、放射性皮炎、肝肾功能异常及血小板降低等毒副作用发生率均基本一致(P> 0. 05)。结论阿帕替尼联合立体定向体部放疗可有效提高晚期胰腺癌患者的临床疗效,改善患者生活质量,延长患者生存时间。Objective To observe the effects of apatinib combined with stereotactic body radiotherapy on short-term efficacy,quality of life and long-term efficacy in patients with advanced pancreatic cancer. Methods 62 patients with advanced pancreatic cancer were selected as the participants and randomly divided into the observation group( 31 cases) and the control group( 31 cases). The control group was treated by stereotactic body radiotherapy,while the observation group was treated by apatinib on the base of control group. After treatment,the curative effects were evaluated. Before and after treatment,the quality of life of the 2 groups of patients were evaluated,including emotional function,social function,somatic function and cognitive function. After treatment,two years-followed up have been performed in the 2 groups,including 1-year survival rate,2-year survival rate,diseasefree progression survival time( PFS) and total survival time( OS). During the treatment,the toxic effects of the two groups were closely observed,including white blood cell depletion,nausea and vomiting,radioactive enteritis,radioactive dermatitis,abnormal liver and kidney function and thrombocytopenia. Results The total effective rate in the observation group was significantly higher than the control group( P < 0. 05). After the treatment,the scores of emotional function,social function,somatic function and cognitive function in the observation group were significantly higher than the control group( P < 0. 05). After the treatment,the 1-year survival rate,2-year survival rate,PFS and OS in the observation group was significantly higher than the control group( P <0. 05). After the treatment,the rated of blood cell depletion,nausea and vomiting,radioactive enteritis,radioactive dermatitis,abnormal liver and kidney function and thrombocytopenia were similar in the 2 groups( P > 0. 05). Conclusion The method of apatinib combined with stereotactic body radiotherapy in the treatment of advanced pancreatic cancer could improve the clinical efficacy,pro

关 键 词：阿帕替尼 立体定向体部放疗 晚期 胰腺癌 

分 类 号：R735.9[医药卫生—肿瘤]