小肠类器官的构建与应用进展  

Development and application of intestinal organoids

作　　者：尹健一 李幼生[2] 黎介寿 Yin Jianyi;Li Yousheng;Li Jieshou(Department of General Surgery,Jinling Hospital,Nanjing General Hospital of Nanjing Military Command,Nanjing UniversitySchool of Medicine,Nanjing 210002,China;Department of General Surgery,the Ninth Peopley's Hospital Affiliatedto Medical College of Shanghai Jiaotong University,Shanghai 200011,China)

机构地区：[1]南京大学医学院附属金陵医院南京军区南京总医院普通外科,210002 [2]上海交通大学医学院附属第九人民医院普通外科,200011

出　　处：《中华实验外科杂志》2019年第7期1344-1347,共4页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金(81270945).

摘　　要：小肠类器官是一种衍生于小肠干细胞或前体细胞的类器官模型.小肠类器官在组织架构及生理功能等方面与小肠上皮高度相似,为小肠健康与疾病的研究提供了全新的平台.本文对小肠类器官近年的研究与应用进展作一综述.Intestinal organoids are ex vivo organoid cultures derived from intestinal stem cells or progenitor cells. Intestinal organoids faithfully recapitulate the architectures and physiological functions of intestinal epithelium and provide a new tool to study intestinal health and disease. This paper reviews the recent advances in the study and application of intestinal organoids.

关 键 词：小肠干细胞 小肠类器官 

分 类 号：R574[医药卫生—消化系统]