Association between NFE2L2 Gene Polymorphisms and Noise-induced Hearing Loss in a Chinese Population  

作　　者：WANG Bo Shen XU Kai ZHANG Hong PU Yue Pu YIN Li Hong HAN Lei CHEN Lin WANG Ning ZHU Bao Li ZHANG Juan 

机构地区：[1]Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China [2]Department of Prevention and Control for Occupational Disease, Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210009, Jiangsu, China

出　　处：《Biomedical and Environmental Sciences》2019年第6期465-470,共6页生物医学与环境科学（英文版）

基　　金：supported by Outstanding Medical Academic Leaders program of Jiangsu Province [LJ201130];Jiangsu Provincial Youth Medical Talent program [QNRC2016536];Six Talent Peaks Project in Jiangsu Province [WSW-017];Preventive Medicine Foundation of Jiangsu [Y2015049];The Fundamental Research Funds for the Central Universities [3225009404]

摘　　要：Occupatio nal n oise is among the most comm on risks associated with the wellbeing of employees. Occupational exposure to noise causes disabling hearing loss in 16% of adults worldwide.It has bee n ack no wledged that no ise-induced heari ng loss (NIHL) is a multifactorial disease, having both genetic and environ mental factors. NIHL continues to be permanent as well as irreversible, but NIHL can be preve nted. As dem on strated by the latest research, excessive oxidative stress in the cochlea has a close link with the pathogenesis of NIHL. which highlights the fact that appropriate control of oxidative stress is a productive strategy for preve nting the in crease in prevale nee and progression of NIHL.

关 键 词：NFE2L2 GENE POLYMORPHISMS CHINESE POPULATION 

分 类 号：Q[生物学]