首发单纯抽动障碍患儿注意认知的事件相关电位研究  

Study on attention cognitive function and event-related potential in the children with the first-episode tic disorder

作　　者：张毅力[1] 任艳玲[1] 马岭[1] 蔡婧[1] 王苏弘[1] Zhang Yili;Ren Yanling;Ma Ling;Cai Jing;Wang Suhong(Department of Neuroscience,The Third Affiliated Hospital of Soochow University,Changzhou 213003,China)

机构地区：[1]苏州大学附属第三医院脑科学研究中心,常州213003

出　　处：《中华行为医学与脑科学杂志》2019年第5期427-430,共4页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金项目(81101018);江苏省科学技术厅第五期"333工程"科研项目自主计划(RBA201711);常州市科技局应用基础研究计划(CJ20160458).

摘　　要：目的通过对首发抽动障碍(tic disorders,TD)患儿Oddball任务行为学及事件相关电位(event-related potentials,ERP)的研究,探讨注意定向功能的变化。方法选取TD患儿、正常儿童各30名,对全部被试进行Oddball任务检测,对行为学结果及P300的亚成分P3a、P3b进行分析。结果TD患儿的击中数[49(48,50)次]低于正常儿童[50(49,50)次](P<0.05),P3a波幅的分组主效应(F=6.047,P=0.015)、分组×条件交互效应显著(F=4.619,P=0.034),TD患儿靶P3a波幅[(5.91±4.51)μV]显著低于正常对照儿童[(9.57±5.80)μV](P<0.05)。而P3a潜伏期、P3b波幅与潜伏期分组×条件交互效应均不显著(P>0.05)。结论首发抽动障碍患儿对新奇刺激的注意定向可能存在损害。Objective To explore the changes of attention cognitive function by studying Oddball task behavior and event-related potentials(ERPs)in children with first-episode tic disorder(TD).Methods Oddball task was tested in 30 children with TD and 30 normal children,and their behavioral data and P3a/P3b components of ERPs were analyzed.Results Children with TD had a lower hitting number(49(48,50))than control group(50(49,50),P<0.05).The main effect of group(F=6.047,P=0.015)and the interaction effect between group and condition(F=4.619,P=0.034)on the amplitude of P3a were significant(P<0.05).The amplitude of P3a component((5.91±4.51)μV)in TD group were smaller than that in the control group((9.57±5.80)μV)(P<0.05).However,there was no significant interaction effect between group and condition on P3a latency,P3b amplitude and latency(P>0.05).Conclusion Attentional orienting is impaired in children with TD.

关 键 词：抽动障碍 Oddball任务 P300 P3A P3B 注意 

分 类 号：R749.94[医药卫生—神经病学与精神病学]