童年期创伤与抑郁症的关系  

The relationship between childhood trauma and depression

作　　者：王蕾蕾 宋崇升 石超[1] 卞清涛[1] Wang Leilei;Song Chongsheng;Shi Chao;Bian Qingtao(The First Clinical Department,Peking University Huilongguan Clinical Medical School,Beijing Huilongguan Hospital,Beijing 100096,China)

机构地区：[1]北京大学回龙观临床医学院,北京回龙观医院临床一科,100096

出　　处：《中华行为医学与脑科学杂志》2019年第5期476-480,共5页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：北京市自然科学基金项目(7172104).

摘　　要：抑郁症的发生与许多因素相关,目前研究主要集中在生物化学、神经内分泌与免疫、遗传因素等生物学方面。而童年期创伤,作为有重要影响的心理因素,其与抑郁症的关系尚未引起公众足够的重视。因此,对两者关系的探讨总结具有重要的意义。较多文献显示,童年期创伤会显著增加抑郁症的患病率,对于抑郁症患者的临床特征及治疗均有较多的影响,其机制可能与创伤所导致的认知心理模式的改变有一定的关系;此外,童年期创伤对抑郁症患者的表观遗传、大脑结构的改变也有一定的影响。基于以上发现,公众对童年期的心理健康问题应予以重视,尽量减少或避免童年创伤,从而减少抑郁症的发生。The occurrence of depression is related to many factors,and the current research mainly focus on biological aspects such as biochemistry,neuroendocrine and immune,and genetic factors.However,as an important psychological factor,the relationship between childhood trauma and depression has not been paid enough attention.Therefore,it is important to discuss and summarize the relationship between them.Many literatures have shown that childhood trauma can significantly increase the prevalence of depression,which has a great impact on the clinical characteristics and treatment of patients with depression.The mechanism may be related to the changes in cognitive and psychological patterns caused by trauma.In addition,childhood trauma can affect the epigenetics and brain structure of patients with depression.Based on the above findings,the public should pay attention to the mental health problems in childhood,minimize or avoid childhood trauma,so as to reduce the occurrence of depression.

关 键 词：抑郁症 童年期创伤 临床特征 

分 类 号：R749.4[医药卫生—神经病学与精神病学]