老年痴呆患者血浆Hcy及NO表达对疾病预后的影响  

Effect of plasma Hcy and NO expression on the prognosis of patients with Alzhei-mer's disease

作　　者：张彩霞[1] 王栋印 张继东 周俐红[1] 张芳芳[1] 张宁[1] Zhang Caixia;Wang Dongyin;Zhang Jidong;Zhou Lihong;Zhang Fangfang;Zhang Ning((First authors adderss Xinxiang Central Hospital,Xinxiang 453000,Henan,China)

机构地区：[1]新乡市中心医院,河南新乡453000 [2]辉县市人民医院,河南辉县453600 [3]辉县市第二人民医院,河南辉县453600

出　　处：《临床心身疾病杂志》2019年第4期1-4,共4页Journal of Clinical Psychosomatic Diseases

摘　　要：目的探讨老年痴呆患者血浆同型半胱氨酸及一氧化氮表达水平与预后的相关性.方法将86例老年痴呆患者按疾病严重程度分为轻度组、中度组与重度组,按生活自理能力分为无需依赖组、轻度依赖组、中度依赖组、重度依赖组,选取同期42名老年健康体检者设为对照组.比较不同认知功能组及对照组血浆同型半胱氨酸及一氧化氮表达水平,比较不同自理能力组及对照组血浆同型半胱氨酸及一氧化氮表达水平,分析血浆同型半胱氨酸、一氧化氮表达水平与认知功能及自理能力的相关性.结果不同疾病严重程度组血浆同型半胱氨酸表达水平依次为:重度组>中度组>轻度组>对照组,差异有统计学意义(P<0.01),血浆一氧化氮表达水平依次为:重度组<中度组<轻度组<对照组,差异有统计学意义(P<0.01).不同自理能力组血浆同型半胱氨酸表达水平依次为:重度依赖组>中度依赖组>轻度依赖组>无需依赖组>对照组,差异有统计学意义(P<0.01),血浆一氧化氮表达水平依次为:重度依赖组<中度依赖组<轻度依赖组<无需依赖组<对照组,差异有统计学意义(P<0.01).血浆同型半胱氨酸表达水平与老年痴呆患者疾病严重程度呈显著正相关(P<0.01),血浆一氧化氮表达水平与老年痴呆患者疾病严重程度呈显著负相关(P<0.05).血浆同型半胱氨酸表达水平与老年痴呆患者的自理能力呈显著负相关(P<0.05),血浆一氧化氮表达水平与老年痴呆患者的自理能力呈显著正相关(P<0.05).结论老年痴呆患者血浆同型半胱氨酸表达较健康者明显升高,一氧化氮表达明显降低,且血浆同型半胱氨酸与一氧化氮表达水平与其预后存在相关性.Objective To investigate the expression of plasma Hcy and NO in patients with Alzheimer's disease and their correlation with prognosis.Methods 86 patients with Alzheimer's disease were divided into mild,moderate and severe groups according to the severity of the disease.According to the ability of self-care,they were divided into no dependent group,mild dependent group,moderate dependent group, and heavily dependent group.And 42 elderly health checkups were selected as the control group.Compare the plasma Hcy and NO expression levels in different cognitive function groups and control group.Com-pare the plasma Hcy and NO expression levels in different self-care ability groups and control group.The correlation between plasma Hcy and NO expression levels and cognitive function and self-care ability were analyzed.Results The plasma Hcy expression levels in different severity groups were as follows :severe group > moderate group > mild group > control group,the difference was statistically significant ( P<0.01).Plasma N O expression levels were as follows :severe group < moderate group < mild group <control group,the difference was statistically significant ( P<0.01).The plasma Hcy expression levels of the different self-care ability groups were as follows :severely dependent group > moderately dependent group > mildly dependent group > no dependent group > control group,the difference was statisti-cally significant ( P<0.01).Plasma NO expres-sion levels were as follows :severely dependent group <moderately dependent group < mildly dependent group < no dependence group < control group, the difference was statistically significant ( P<0.01).The level of plasma ho mocysteine was positively correlated with the severity of alzheimer's disease ( P< 0.01),and the level of plasma nitric oxide was negatively correlated with the severity of alzheimer's disease ( P< 0.05).There was a significant negative correlation between plasma Hcy expression and self-care ability in elderly patients with AD (P<0.05).There was a significant

关 键 词：老年痴呆 同型半胱氨酸 一氧化氮 简易智力状态量表 Barthal指数 预后 

分 类 号：R749.16[医药卫生—神经病学与精神病学]