复合式小梁切除术联合康柏西普玻璃体腔注射治疗新生血管性青光眼效果分析  

Effect analysis of complex trabeculectomy combined with Con-bercept intravitreal injection in the treatment of neovascular glaucoma

作　　者：李慧俐 韩新刚 孙雅楠 Li Huili;Han Xingang;Sun Yanan(Pingmei Shen ma Medical Group General Hospital,Pingdingshan 467000,Henan,China)

机构地区：[1]平煤神马医疗集团总医院,河南平顶山467000

出　　处：《临床心身疾病杂志》2019年第4期123-125,131,共4页Journal of Clinical Psychosomatic Diseases

摘　　要：目的探讨复合式小梁切除术联合康柏西普玻璃体腔注射治疗新生血管性青光眼的临床疗效.方法将96例新生血管性青光眼患者按照随机数字表法分为研究组与对照组各48例.两组均给予复合式小梁切除术,研究组在术前5d—7d给予康柏西普玻璃体腔注射治疗,比较两组虹膜新生血管消退时间,比较两组手术前后眼压及视力水平,血清白细胞介素-6、血管内皮生长因子、转化生长因子β1水平,比较两组并发症发生率.结果研究组虹膜新生血管消退时间显著短于对照组(P<0.01).术后1个月、3个月两组眼压较术前显著降低(P<0.01),研究组显著低于对照组(P<0.01),两组视力水平较术前显著升高(P<0.01),研究组显著高于对照组(P<0.01).术后1d两组血清白细胞介素-6、血管内皮生长因子、转化生长因子β1水平均较术前显著降低(P<0.01),研究组显著低于对照组(P<0.01).两组并发症发生率比较差异无统计学意义(P>0.05).结论可促使虹膜新生血管消退,降低患者眼压及血清白细胞介素-6、血管内皮生长因子、转化生长因子β1水平,提高视力水平,安全性高,值得推广应用.Objective To explore the effect of complex trabeculectomy combined with Conbercept intravitreal injection in the treatment of neovascular glaucoma.Methods 96 patients with NVG were randomly divided into control group and study group,48 cases in each group.The two groups were all given complex trabeculectomy.The study group was treated with Conbercept intravitreal injection at 5-7 d before surgery.The iris neovascularization retrogression time,intraocular pressure and vision level before and after operation,levels of serum interleukin-6 (IL-6),vascular endothelial growth factor (V EGF),transforming growth factor beta 1 (TGF-beta 1) and the incidence of complications were compared between the two groups.Results The retrogression time of iris neovascularization in the study group was significantly shorter than that of the control group ( P<0.01).At 1 month and 3 months af ter operation,the intraocular pressure of the two groups was significantly lower than that before operation (P<0.01),and the study group was significantly lower than the control group ( P<0.01).The visual acuity of the two groups was significantly higher than that before surgery ( P<0.01),and the study group was significantly higher than the control group ( P<0.01).1 d after surgery,the levels of serum interleukin-6,vascular endothelial growth factor,transforming growth factor beta 1 were significantly lower than those before surgery ( P<0.01).The study group was significantly lower than the control group ( P<0.01).There was no significant difference in the incidence of complications between the two groups ( P>0.05).Conclusion Complex trabeculectomy com bined with Conbercept intravitreal injection can promote the retrogression of iris neo-vascularization,reduce intraocular pressure and serum interleukin-6,vascular endothelial growth factor and transforming growth factor beta 1 levels.It can also improve the level of vision,with high security,it is worth promoting.

关 键 词：新生血管性青光眼 康柏西普 玻璃体腔注射 复合式小梁切除术 虹膜新生血管 眼压 

分 类 号：R775[医药卫生—眼科]