阻塞性睡眠呼吸暂停与脑卒中相关性的研究进展  

Advance in Relationship between Obstructive Sleep Apnea and Stroke(review)

作　　者：陈敬绵[1] 李宗军 李培兰[1] 张通[1] CHEN Jing-mian;LI Zong-jun;LI Pei-lan;ZHANG Tong(Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China)

机构地区：[1]中国康复研究中心北京博爱医院

出　　处：《中国康复理论与实践》2019年第7期783-787,共5页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：阻塞性睡眠呼吸暂停(OSA)可以增加脑卒中风险,脑卒中患者也易于并发OSA.高龄、高体质量指数、男性、高血压和糖尿病为OSA患者并发脑卒中的危险因素,严重的睡眠呼吸暂停与脑卒中后神经功能不良预后相关.OSA后内皮功能紊乱、神经调节异常、代谢异常、脑血流动力学改变、高凝状态等多种病理生理机制可能导致脑卒中.持续正压通气(CPAP)是中重度OSA患者的标准治疗方法,但尚不能证实CPAP可降低OSA患者发生包括脑卒中在内的心血管事件的风险.Obstructive sleep apnea (OSA) may increase the risk of stroke, and patients with stroke are also prone to suffer OSA. Advanced age, high body mass index, male, hypertension and diabetes are risk factors for stoke in OSA patients, and severe sleep apnea may also be associated with poor functional outcomes of stroke. Potential pathophysiological mechanisms may include endothelial dysfunction, abnormal neuromodulation, metabolic abnormalities, change of cerebral hemodynamic and hypercoagulability. Continuous positive airway pressure (CPAP) is the standard treatment for patients with moderate to severe OSA, but it has not been proved that CPAP can reduce the risk of cardiovascular events including stroke.

关 键 词：阻塞性睡眠呼吸暂停 脑卒中 流行病学 病理生理 综述 

分 类 号：R743.3[医药卫生—神经病学与精神病学]