SMAD2和SGK3在非小细胞肺癌中的表达及临床意义  

Expression and clinical significance of SMAD2 and SGK3 in non-small cell lung cancer

作　　者：李瑞[1] 任鹏飞[1] 温艳艳 陈永芳[1] 陈裕[1] LI Rui;REN Peng-fei;WEN Yan-yan;CHEN Yong-fang;CHEN Yu(Department of Geriatric Tuberculosis,the Sixth People's Hospital of Zhengzhou,Zhengzhou,Henan 450000,China)

机构地区：[1]郑州市第六人民医院老年结核病科,河南郑州450000 [2]安阳市肿瘤医院肿瘤科,河南安阳455001

出　　处：《临床肺科杂志》2019年第8期1498-1503,共6页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨细胞信号传导分子SMAD2和血清和糖皮质激素诱导的蛋白激酶3(Serum and glucocorticoid-inducible protein kinase 3,SGK3)在非小细胞肺癌(Non small cell lung cancer,NSCLC)中的表达及临床意义。方法选取郑州市第六人民医院和安阳市肿瘤医院2010年6月至2013年6月收治的98例NSCLC患者作为研究对象,采用系统回顾性分析法分析所有患者的临床资料,根据其资料结果收集98例NSCLC患者其98份癌组织标本(研究组)及98份癌旁组织标本(对照组)作为研究对象,所有组织标本均行SMAD2与SGK3蛋白的检测,并分析二者的表达与NSCLC患者临床病理特征的关系。结果①NSCLC组织中SMAD2与SGK3蛋白阳性表达率分别为77.55%和74.49%,明显高于癌旁组织中SMAD2与SGK3蛋白阳性表达(17.35%与15.31%)(P<0.05);②SMAD2蛋白表达与NSCLC患者性别、年龄、病理类型、肿瘤大小均无明显关系(P>0.05);SMAD2蛋白表达与NSCLC患者肿瘤分化程度、淋巴结转移存在显著相关性(P<0.05);③SGK3蛋白表达与NSCLC患者性别、年龄、病理类型、肿瘤大小均无明显关系(P>0.05);SGK3蛋白表达与NSCLC患者肿瘤分化程度、淋巴结转移存在显著相关性(P<0.05);④经单因素分析得出:低分化、淋巴结转移、SMAD2蛋白阳性表达、SGK3蛋白阳性表达患者生存时间均显著缩短(P<0.05);⑤经多因素Cox分析得出:低分化、有淋巴结转移、SMAD2蛋白阳性、SGK3蛋白阳性均为影响NSCLC患者预后的独立危险因素(P<0.05)。结论SMAD2与SGK3蛋白在NSCLC组织中表达显著高于癌旁组织,其表达水平与NSCLC患者分化程度、淋巴结转移均有显著相关,可能参与了NSCLC的发生、发展。Objective To investigate the expression levels and clinical significance of SMAD2 and serum and glucocorticoid-inducible protein kinase 3 (SGK3) in non-small cell lung cancer (NSCLC).Methods The clinical data of 98 cases of NSCLC patients in Sixth People's Hospital of Zhengzhou and Anyang Tumour Hospital from June 2010 to June 2013 were analyzed retrospectively.The protein expression levels of SMAD2 and SGK3 in cancer tissues (n=98,the study group) and adjacent normal tissues (n=98,the control group) collected from the selected patients were detected.Then its correlation with clinicopathological features was analyzed.Results ① The positive rates of SMAD2 and SGK3 protein in NSCLC tissues were 77.55% and 74.49% respectively,which were significantly higher than that in adjacent tissues (17.35% and 15.31%)( P< 0.05).② The protein expression level of SMAD2 had no correlation with gender,age,pathological type and tumor size of NSCLC patients ( P> 0.05),while it was correlated with the differentiation degree and lymph node metastasis ( P< 0.05).③ The protein expression levels of SGK3 was not correlated with gender,age,pathological type and tumor size of NSCLC patients ( P> 0.05),while it was correlated with the differentiation degree and lymph node metastasis ( P< 0.05).④ Univariate analysis showed that the survival time of patients with poor differentiation,lymph node metastasis,positive expression of SMAD2 protein and positive expression of SGK3 protein were significantly shorter ( P< 0.05).⑤ Multivariate Cox analysis showed that poor differentiation,lymph node metastasis,positive SMAD2 protein and positive SGK3 protein were independent risk factors for the prognosis of patients with NSCLC ( P< 0.05).Conclusion The expression of SMAD2 and SGK3 protein in NSCLC tissues is significantly higher than that in adjacent tissues,which is significantly correlated with the differentiation degree and lymph node metastasis of NSCLC patients,indicating that the two indicators have significant correlation with the occurr

关 键 词：非小细胞肺癌 细胞信号传导分子SMAD2 血清和糖皮质激素诱导的蛋白激酶3 免疫组织化学 临床病理特征 

分 类 号：R734.2[医药卫生—肿瘤]