乳腺癌组织中BRCA1、ALDH1及nm23的表达及临床意义  

Expression and clinical significance of BRCA1, ALDH1 and nm23 on breast cancer

作　　者：吴立刚 宁明亮 刘清媛 纳莉[2] WU Ligang;NING Mingliang;LIU Qingyuan;NA Li(The Third Surgical Oncology Department of Tumor Hospital, General Hospital of Ningxia Medical University,Yinchuan 750004,China;The Third Surgical Oncology Department of Tumor Hospital,Surgery Laboratory, General Hospital of Ningxia Medical University,Yinchuan 750004,China)

机构地区：[1]宁夏医科大学总医院肿瘤医院肿瘤外三科,宁夏银川750004 [2]宁夏医科大学总医院外科学研究室,宁夏银川750004

出　　处：《西部医学》2019年第7期1006-1009,共4页Medical Journal of West China

摘　　要：目的探讨乳腺癌组织中BRCA1、ALDH1及nm23的表达及临床意义。方法纳入2002~2008年在宁夏医科大学总医院肿瘤医院肿瘤外科手术治疗的乳腺癌患者836例为研究对象,随访确定术后5年内因乳腺癌死亡患者为死亡组(n=49),无瘤生存乳腺癌患者作为对照组(n=49)。应用免疫组织化学染色法检测BRCA1、ALDH1、nm23在乳腺癌组织中的表达,采用Spearman’s等级相关分析BRCA1、ALDH1、nm23的相关性。结果死亡组BRCA1和nm23表达低于对照组(P<0.05),ALDH1表达高于对照组(P<0.05);乳腺癌组织中ALDH1与BRCA1、nm23呈负相关(P<0.05),BRCA1与nm23呈正相关(P<0.05)。结论 BRCA1、ALDH1、nm23在乳腺癌组织中存在差异表达,其共同检测有望成为预测乳腺癌预后及指导治疗的生物学指标。Objective To explore the expression and clinical significance of BRCA1, ALDH1 and nm23 on breast cancer. Methods There are 836 patients with operable breast cancer diagnosed in Oncological Surgery of Affiliated Hospital of Ningxia Medical University from 2002 to 2008 were recruited. The patients were divided into death group and control group after following up for 5 years. Protein expressions of BRCA1, ALDH1 and nm23 in cancer tissue were assayed by immune-histochemical staining. Spearman’s means was used to analyze the correlation of BRAC1, ALDH1 and nm23. Results Protein expression of BRCA1 and nm23 were lower in death group than control group. Expression of ALDH1 was increased in death group compared to the control group. Expression of ALDH1 in cancer tissue was negative correlated to BRCA1 and nm23, and expression of BRCA1 was positive to nm23. Conclusion Joint detection of BRCA1, ALDH1 and nm23 might be a biological marker for forecasting prognosis and directing therapy of breast cancer.

关 键 词：乳腺癌易感基因1 乙醛脱氢酶1 NM23 乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]