重组组织型纤溶酶原激活剂静脉溶栓治疗不同年龄段急性脑梗死的临床疗效观察  

The clinic effect of rt-PA intravenous thrombolysis in the treatment of acute cerebral infarction of different age groups

作　　者：王秀容[1] 喻明[1] WANG Xiu-rong;YU Ming(Department of Neurology,Suining Central Hospital,Suining 629000,China)

机构地区：[1]四川省遂宁市中心医院神经内科

出　　处：《实用医院临床杂志》2019年第4期111-114,共4页Practical Journal of Clinical Medicine

摘　　要：目的观察重组组织型纤溶酶原激活物(rt-PA)静脉溶栓治疗不同年龄段急性脑梗死的临床疗效及安全性。方法选择rt-PA静脉溶栓治疗急性脑梗死患者209例,其中50~60岁组52例,60~70岁组58例,70~80岁组51例,80岁以上组48例,比较四组临床疗效及安全性。结果治疗后50~60岁组患者临床治疗总有效率优于60~70岁组、70~80岁组和80岁以上组(P<0. 05),NIHSS评分及mRs评分低于60~70岁组、70~80岁组和80岁以上组(P<0. 05),24 h内出血率及90d内死亡率也低于其他三组,差异有统计学意义(P<0. 05)。结论不同年龄患者均可以在静脉溶栓治疗中获益,低龄患者较高龄患者获益程度更高,预后相对更好。Objective To observe the efficacy and safety of recombinant tissue plasminogen activator(rt-PA) intravenous thrombolysis in the treatment of acute cerebral infarction of different age groups.Methods Two hundred and nine patients with acute cerebral infarction treated with rt-PA intravenous thrombolysis were divided into four age groups,including 52 patients in 50 ~ 60 years old group,58 patients in 60 ~ 70 years old group,51 patients in 70 ~ 80 years old group and 48 patients in over 80 years old group.The clinical effect and safety were compared among the four groups.Results The clinical curative effect of the 50 ~ 60 years old group was better than another three groups(P < 0. 05).NIHSS score and mRs score in the 50 ~ 60 years old group were lower than those in another three groups(P < 0. 05).The risk of bleeding within 24 hours and mortality were also lower in the 50 ~ 60 years old group than those in another three groups(P < 0. 05). Conclusion Patients of different ages can have benefit from intravenous thrombolysis therapy.Younger patients have higher benefit and better prognosis than older patients.

关 键 词：急性脑梗死 重组组织型纤溶酶原激活物 临床疗效 

分 类 号：R743.3[医药卫生—神经病学与精神病学]