氯替泼诺结合氧氟沙星对老年白内障患者术后眼内炎症和感染的影响  

The effects of loteprednol combined with ofloxacin on postoperative intraocular inflammation and infection in elderly patients with cataract

作　　者：唐智深 陈凯 周华芬 TANG Zhi-shen;CHEN Kai;ZHOU Hua-fen(Department of Ophthalmology,West China Guang'an Hospital,Sichuan University,Guang'an 638000,China)

机构地区：[1]四川大学华西广安医院眼科

出　　处：《实用医院临床杂志》2019年第4期118-121,共4页Practical Journal of Clinical Medicine

摘　　要：目的探讨氯替泼诺结合氧氟沙星对老年白内障患者术后眼内炎症和感染的影响。方法我院84例(84眼)行白内障超声乳化吸出+人工晶状体植入术治疗的老年白内障患者,采用随机数字表法分为对照组及观察组各42例。对照组术后予氧氟沙星+妥布霉素地塞米松滴眼治疗,观察组术后予氧氟沙星+氯替泼诺妥布霉素滴眼治疗。比较两组术后1、7、14 d结膜充血评分、房水闪辉评分、前房容积、切口处角膜厚度和眼压变化情况,记录眼内炎及眼压升高发生情况。结果两组术后14 d结膜充血评分、房水闪辉评分、前房容积、切口处角膜厚度均低于术后7 d及1 d,术后7 d低于术后1 d(P<0. 05);两组术后各时间点结膜充血评分、房水闪辉评分、前房容积、切口处角膜厚度比较,差异无统计学意义(P>0. 05)。观察组术后7 d眼压高于术后1 d及14 d,术后14 d高于术后1 d(P<0. 05);对照组术后7 d与14 d眼压比较,差异无统计学意义(P>0. 05),但均高于术后1 d(P<0. 05);两组术后1 d眼压比较,差异无统计学意义(P>0. 05);但观察组术后7、14 d眼压均低于对照组(P<0. 05)。两组术后均未出现眼内炎,且两组眼压升高发生率比较,差异无统计学意义(P>0. 05)。结论氯替泼诺结合氧氟沙星能有效抑制老年白内障患者术后眼内炎症及感染,还可避免发生眼压升高等不良反应,具有较高的应用安全性。Objective To explore the effects of loteprednol combined with ofloxacin on postoperative intraocular inflammation and infection in elderly patients with cataract.Methods Eighty-four elderly patients(84 eyes) with cataract who underwent phacoemulsification and intraocular lens implantation in our hospital were selected for the study.The patients were divided into control or observation group according to the random number table method,42 in each group.The control group was given ofloxacin + tobramycin and dexamethasone eye drops after operation,and the observation group was given ofloxacin + loteprednol and tobramycin eye drops after operation.The changes of conjunctival hyperemia score,aqueous flare score,anterior chamber volume,corneal thickness at incision and intraocular pressure were compared between the two groups after 1 day,7 and 14 days of operation.The occurrence of intraocular inflammation and increased intraocular pressure was recorded.Results After 14 days of operation,the conjunctival hyperemia score,aqueous flare score,anterior chamber volume and corneal thickness at incision in the two groups were lower than those after 7 days and 1 day of operation,and 7 days were lower than 1 day of operation(P<0. 05).However,there were no significant differences in the indexes above at each time point after operation between the two groups(P>0. 05).The intraocular pressure in the observation group after 7 days of operation was significantly higher than that after 1 day and 14 days of operation(P<0. 05),and 14 days were higher than 1 day(P<0. 05).In the control group,there was no statistically significant difference in the intraocular pressure between 7 and 14 days after operation(P>0. 05),but the intraocular pressure was higher than that after 1 day of operation( P<0. 05).There was no significant difference in the intraocular pressure after 1 day of operation between the two groups(P>0. 05).The intraocular pressure in the observation group was lower than that in control group after 7 and 14 days of operation(P<0

关 键 词：老年白内障 氯替泼诺 氧氟沙星 眼内炎 眼压 

分 类 号：R776.1[医药卫生—眼科]