A systematic quantitative method for quality evaluation of Bupleurum chinense DC. based on multi-wavelength fusion fingerprint combined with multivariate chemometrics  

作　　者：Ye Zhu Ran Wen Yaping Yu Wei Wei Guoxiang Sun 

机构地区：[1]School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, China

出　　处：《Asian Journal of Traditional Medicines》2019年第2期65-81,共17页亚洲传统医药（英文）

基　　金：the National Natural Science Foundation of China (Accession no. 81573586, 90612002).

摘　　要：A quantitative evaluation method for the quality consistency of Bupleurum chinense DC. was developed by combining multiwavelength fusion fingerprint with chemometric methods. The fingerprint information of Bupleurum at five wavelengths (210, 254, 265, 280 and 320 nm) collected by HPLC-DAD instrument was fused to overall control its quality. The fusion fingerprints and four components (saikosaponin a, saikosaponin d, rutin, quercitrin) were studied by systematic quantitative fingerprint method and principal component analysis, respectively. Besides, fingerprint-efficacy relationship was constructed in vitro using partial least-squares model. In conclusion, all work can serve as a valid reference for the quality control of Bupleurum .

关 键 词：CHEMOMETRICS fingerprint-efficacy relationship fusion FINGERPRINT BUPLEURUM chinense DC. quality CONSISTENCY 

分 类 号：R[医药卫生]