乳腺浸润性导管癌的超声征象与CD34表达的相关性  

Correlation between ultrasonographic features and CD34 expression in invasive ductal carcinoma of the breast

作　　者：颜丽华 章婧文 王伟镇[1] 刘志 刘娟[1] 王宝平[1] 纪丽景[1] 李璇[1] 马焕容 YAN Lihua;ZHANG Jingwen;WANG Weizhen;LIU Zhi;LIU Juan;WANG Baoping;JI Lijing;LI Xuan;MA Huanrong(Department of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China)

机构地区：[1]南方医科大学南方医院超声医学科

出　　处：《分子影像学杂志》2019年第3期290-293,共4页Journal of Molecular Imaging

基　　金：国家自然科学基金(81801720);南方医科大学南方医院院长基金(2017C015)

摘　　要：目的分析乳腺浸润性导管癌的超声征象与癌组织CD34表达的相关性。方法通过肿瘤基因图谱数据库分析乳腺浸润性导管癌组织中CD34与血管生成相关因子的编码基因VEGFA、VEGFR、PDGFR表达水平的相关性;回顾性分析经病理确诊的100例乳腺浸润性导管癌患者的超声征象与CD34的免疫组化染色结果,分析二者的相关性。结果乳腺浸润性导管癌组织中CD34与VEGFA的mRNA水平不存在明显相关关系,与VEGFR、PDGFR的mRNA水平存在显著正相关关系。乳腺浸润性导管癌的超声征象中,血流显像分级为Ⅱ~Ⅲ级者,癌组织中CD34高表达的比例高于0~Ⅰ级者;腋窝淋巴结转移者,CD34高表达的比例高于无转移者。结论乳腺浸润性导管癌超声征象中血流分级及腋窝淋巴结转移与CD34表达显著正相关,提示临床医师可结合CD34与超声征象为患者进行抗血管治疗用药的选择分析。Objective To analyze the correlations between the ultrasonographic features and CD34 expression in invasive ductal carcinoma of the breast. Methods The expression of CD34 in invasive ductal carcinoma of the breast and its correlations with genes (VEGFA, VEGFR and PDGFR) that encoding angiogenesis-related factors were analyzed by the cancer genome atlas. We retrospectively analyzed the ultrasonographic features and CD34 immunohistochemical staining of 100 patients with pathologically diagnosed invasive ductal carcinoma of the breast. Their correlation was analyzed. Results There was no significant correlation between CD34 and VEGFA at mRNA levels in breast invasive ductal carcinoma. There was a significant positive correlation between CD34 and VEGFR/PDGFR at mRNA levels. Among all the ultrasonographic features, invasive ductal carcinoma of the breast with blood flow of grade Ⅱ~Ⅲ had a higher expression of CD34 than that of grade 0~Ⅰ. The invasive ductal carcinoma of the breast with axillary lymph node metastasis had a higher expression of CD34 than that without metastasis. Conclusion Among all the ultrasonographic features, the blood flow grading and axillary lymph nodes metastasis are associated with CD34 expression. The clinicians may select anti-angiogenic drugs for patients based on both CD34 and ultrasonographic features.

关 键 词：乳腺浸润性导管癌 超声征象 CD34 

分 类 号：R737.9[医药卫生—肿瘤]