粪菌移植在炎症性肠病中的应用进展  

Therapeutic application of fecal microbiota transplantation in inflammatory bowel disease

作　　者：陈嘉楠 吴思丽 邱欣帆 李志锋 程淇 毛华[2] CHEN Jianan;WU Sili;QIU Xinfan;LI Zhifeng;CHENG Qi;MAO Hua(The Second Clinical Medical School of Southern Medical University, Guangzhou 510515, China;Department of Gastroenterology, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, China)

机构地区：[1]南方医科大学第二临床医学院,广东广州510515 [2]南方医科大学珠江医院消化内科,广东广州510282

出　　处：《分子影像学杂志》2019年第3期353-357,共5页Journal of Molecular Imaging

基　　金：南方医科大学大学生创新训练项目省级课题(201812121178)

摘　　要：炎症性肠病是一组慢性非特异性肠道炎症性疾病,包括溃疡性结肠炎和克罗恩病,其发病原因尚不明确,研究表明肠道菌群紊乱在炎症性肠病的发病中起重要作用,而粪菌移植作为一种可以重建肠道菌群的疗法,在炎症性肠病的临床应用上有重要价值。粪菌移植是将健康个体的粪便处理成混悬液,输注到炎症性肠病患者消化道内,重建肠道微生态,从而有效缓解炎症性肠病病情。但目前粪菌移植在炎症性肠病上的临床应用仍存在不少问题,如供体的筛选、粪菌液的制备、移植的途径及频次等方面均未形成共识。本文就粪菌移植的在炎症性肠病中的应用进展进行综述。Inflammatory bowel disease(IBD)is a group of chronic non-specific intestinal inflammatory diseases, including ulcerative colitis(UC)and Crohn’s disease(CD).The causes are not clear. The intestinal flora disorder plays an important role in the pathogenesis of IBD. Fecal microbiota transplantation can reconstruct intestinal flora.It has great value in the clinical application of IBD. Fecal microbiota transplantation treat the feces of healthy individuals into suspension.It infuses them into the digestive tract of ibd patients, and reconstruct intestinal microecology, so as to effectively alleviate the condition of IBD patients. However, the problems exist in the clinical application of fecal microbiota transplantation in IBD, such as the selection of donors, the preparation of fecal bacteria solution, the way and frequency of transplantation. This review summarizes the therapeutic application of fecal microbiota transplantation in IBD.

关 键 词：粪菌移植 炎症性肠病 溃疡性结肠炎 克罗恩病 

分 类 号：R574[医药卫生—消化系统]