IAP抑制剂增强TRAIL诱导肿瘤细胞凋亡的研究进展  

Research Advances in IAP Inhibitors-enhanced TRAIL-induced Tumor Cell Apoptosis

作　　者：郝金莉 罗保斌 魏燕妮 李慧萍[1] HAO Jin-li;LUO Bao-bin;WEI Yan-ni;LI Hui-ping(Clinical Laboratory,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;Wei Fang Nursing Vocational College,Wei Fang,Shandong 262500,China)

机构地区：[1]北京中医药大学东直门医院检验科,北京100700 [2]潍坊护理职业学院,山东潍坊262500

出　　处：《河北北方学院学报（自然科学版）》2019年第6期57-60,共4页Journal of Hebei North University:Natural Science Edition

摘　　要：肿瘤坏死因子相关凋亡诱导配体(tumor necrosis factor-related apoptosis inducing ligand,TRAIL)可高效、特异地诱导肿瘤细胞凋亡,但某些肿瘤细胞对TRAIL介导的细胞凋亡并不敏感。凋亡抑制蛋白(inhibitor of apoptosis proteins,IAPs)抑制剂与TRAIL联合应用能够显著增强TRAIL介导的肿瘤细胞凋亡。综述了IAP抑制剂对TRAIL的协同增效作用及可能的机制。Tumor necrosis factor related apoptosis inducing ligand(TRAIL)can efficiently and specifically induce apoptosis of cancer cells,but some cancer cells are not sensitive to TRAIL-mediated apoptosis.Combination of inhibitor of apoptosis proteins(IAPs)inhibitors and TRAIL can significantly enhance TRAIL-mediated apoptosis of cancer cells.Synergistic effect of IAP inhibitors on TRAIL and its possible mechanism were reviewed.

关 键 词：细胞凋亡 肿瘤坏死因子相关凋亡诱导配体 凋亡抑制蛋白 IAP抑制剂 

分 类 号：R730.5[医药卫生—肿瘤]