血清对氧磷酶1水平在甲胎蛋白阴性原发性肝癌中的诊断价值  

Diagnostic value of serum oxaphosphatase 1 level in α-fetoprotein negative primary liver cancer

作　　者：朱波[1] 吴君荣[1] 舒宏[1] 黄昭东[1] 梁艺华[1] 赵惠柳[1] ZHU Bo;WU Junrong;SHU Hong;HUANG Zhaodong;LIANG Yihua;ZHAO Huiliu(Clinical Laboratory, the Affiliated Cancer Hospital of Guangxi Medical University, Guangxi Zhuang Autonomous Region, Nanning 530021, China)

机构地区：[1]广西医科大学附属肿瘤医院检验科

出　　处：《中国医药导报》2019年第19期156-159,共4页China Medical Herald

基　　金：广西壮族自治区卫生厅医疗重点科研项目(重2012095)

摘　　要：目的探讨对氧磷酶1(PON1)对甲胎蛋白阴性原发性肝癌(AFP-PHC)的诊断价值及界值。方法收集2015年1~12月广西医科大学附属肿瘤医院住院的60例AFP阴性肝硬化(AFP-LC)患者(AFP-LC组)和46例AFP-PHC患者(AFP-PHC组)的血清,用电化学发光免疫分析法检测所有纳入对象血清AFP水平,酶联免疫法检测PON1水平。结果 AFP-PHC组血清PON1水平明显低于AFP-LC组,差异有统计学意义(P <0.05),PON1水平诊断AFP-PHC的受试者工作特征曲线下最大面积为0.768,当PON1水平<234.31 pg/mL,诊断AFP-PHC的敏感性为71.7%,特异性为73.9%。血清PON1水平与AFP-PHC患者肝功能分级、病理分化程度、有无癌栓及乙型肝炎表面抗原是否阳性均无关(P> 0.05)。结论血清PON1水平对诊断AFP-PHC具有一定的效能。Objective To evaluate the diagnostic value and the threshold value of paraoxonase 1 (PON1) in α-fetoprotein negative primary liver cancer (AFP-PHC). Methods From January to December 2015, serum samples of 60 AFP negative cirrhosis patients (AFP-LC group) and 46 AFP-PHC patients (AFP-PHC group) hospitalized in the Affiliated Cancer Hospital of Guangxi Medical University were collected. The serum AFP levels of all included subjects were detected by electrochemoluminescence immunoassay, and PON1 levels were detected by enzyme-linked immunoassay. Results The serum PON1 level in the AFP-PHC group was significantly lower than that in the AFP-LC group, and the difference was statistically significant (P < 0.05), the maximum area under the subject operating characteristic curve for diagnosis of AFP-PHC by PON1 level was 0.768. When PON1 level < 234.31 pg/mL, the sensitivity and specificity of the diagnosis of AFP-PHC were 71.7% and 73.9% respectively. There was no correlation between serum PON1 level and liver function grade, pathological differentiation degree, tumor thrombus or positive hepatitis B surface antigen in patients with AFP-PHC (P > 0.05). Conclusion Serum PON1 level is effective is diagnosing AFP-PHC.

关 键 词：对氧磷酶1 肝硬化 原发性肝癌 甲胎蛋白 

分 类 号：R735.7[医药卫生—肿瘤]