PDX模型在卵巢癌研究中的应用展望  

Application and prospect of PDX model in ovarian cancer researches

作　　者：李巍[1] 杨淑丽[1] 田明[1] 苗劲蔚[1] LI Wei;YANG Shuli;TIAN Ming;MIAO Jinwei(Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100071, China)

机构地区：[1]首都医科大学附属北京妇产医院妇瘤科

出　　处：《中国医药导报》2019年第18期45-48,共4页China Medical Herald

基　　金：首都医科大学附属北京妇产医院北京妇幼保健院中青年学科骨干培养专项课题(fcyy201627);北京市自然科学基金项目(7162063)

摘　　要：卵巢癌是常见的妇科恶性肿瘤,临床表现不典型,主要表现为腹胀、腹部肿物等,病理类型多样,异质性特征明显。肿瘤细胞系模型、转基因动物模型是最为常见的卵巢癌研究模型,应用其取得了长足的进步,但缺点明显。卵巢癌人源肿瘤异种移植瘤(PDX)模型为最新的卵巢癌研究模型,本文概述了卵巢癌PDX模型在卵巢癌研究中的应用基础及前景。Ovarian cancer is a common gynecology oncologic tumor. Its clinical presentations are untypical, mainly including abdominal distension and pelvic mass, et al. The pathologic types of ovarian cancer are varied, so its heterogenicity is obvious. Tumor cell line modals and transgenic animal modals are commonly used ovarian cancer models,and they gain great progress in ovarian cancer researches. But their defects are also inevitable. Ovarian cancer patient derived tumer xenograft(PDX) model is a brand new cancer research model, we summarize the application base and prospect of it PDX model ovarian cancer researches.

关 键 词：卵巢癌 肿瘤异质性 动物模型 人源肿瘤异种移植瘤 

分 类 号：R737.31[医药卫生—肿瘤]