中西医结合治疗对恶性实体瘤患儿5年生存情况的影响  

Effect of integrated traditional Chinese and Western medicine on 5-year survival of children with malignant solid tumors

作　　者：张吉 史学[2] 李海天[3] 祝秀丹[4] 田莉 刘正茂 ZHANG Ji;SHI Xue;LI Haitian;ZHU Xiudan;TIAN Li;LIU Zhengmao(Department of Pediatrics, Mentougou District Hospital of Traditional Chinese Medicine in Beijing City, Beijing 102300, China;Department of Traditional Chinese Medicine, National Children′s Medical Center Beijing Children′s Hospital, Capital Medical University, Beijing 100045, China;Department of Rehabilitation, National Children′s Medical Center Beijing Children′s Hospital, Capital Medical University, Beijing 100045, China;Department of Oncology Surgery, National Children′s Medical Center Beijing Children′s Hospital, Capital Medical University, Beijing 100045, China;Department of Pediatrics, Xuanwu Hospital of Traditional Chinese Medicine in Beijing City, Beijing 100053, China;Department of Pediatrics, Xiangyang Traditional Chinese Medicine Hospital, Hubei Province, Xiangyang 441000, China)

机构地区：[1]北京市门头沟区中医医院儿科,北京102300 [2]国家儿童医学中心首都医科大学附属北京儿童医院中医科,北京100045 [3]国家儿童医学中心首都医科大学附属北京儿童医院康复科,北京100045 [4]国家儿童医学中心首都医科大学附属北京儿童医院肿瘤外科,北京100045 [5]北京宣武中医医院儿科,北京100053 [6]湖北省襄阳市中医医院儿科,湖北襄阳441000

出　　处：《中国医药导报》2019年第18期117-120,共4页China Medical Herald

基　　金：首都医学发展科研基金项目(SF-2009-Ⅱ-13)

摘　　要：目的探讨中西医结合治疗对恶性实体瘤患儿5年生存情况的影响。方法研究对象为2005年1月~2009年12月首都医科大学附属北京儿童医院收治的恶性实体瘤患儿167例,持续回访5年,回访时间截至2015年1月。将符合纳入标准的患儿采用随机数字表法分为治疗组83例,对照组84例,其中治疗组脱落16例为67例,对照组脱落20例为64例。治疗组常规进行化疗、手术治疗及中药治疗;对照组常规进行化疗及手术治疗。比较两组患儿生存时间、生存情况、复发情况。结果治疗组5年生存率为69.0%,对照组5年生存率为46.7%。两组患儿平均生存时间比较差异有高度统计学意义(P <0.01)。两组患儿复发率比较差异无统计学意义(P> 0.05)。两组患儿无病生存情况比较差异有统计学意义(P <0.05)。结论扶正健脾中药结合西医治疗实体瘤患儿能通过减轻化疗不良反应,顺利完成化疗,延长生存时间,提高其存活率,改善其生存质量。Objective To explore the effect on 5-year survival of integrated traditional Chinese and Western medicine to children with malignant solid tumors. Methods The subjects were 167 children with malignant solid tumors admitted to Beijing Children′s Hospital, Capital Medical University from January 2005 to December 2009, continuous return visit for 5 years, up to January 2015. The children who met the inclusion criteria were divided into treatment group(83 cases)and control group(84 cases) by random number table method. Among them, there were 67 cases in treatment group(16 cases of exfoliation) and 64 cases in control group(20 cases of exfoliation). The treatment group received routine chemotherapy, surgery and traditional Chinese medicine, while the control group received routine chemotherapy and surgery. The survival time, survival and recurrence conditions of two groups were compared. Results The 5-year survival rate was 69.0% in treatment group and 46.7% in control group, there was significant difference in the average sur vival time between two groups(P < 0.01). There was no significant difference in recurrence rate between two groups(P >0.05). There was significant difference in disease-free survival between two groups(P < 0.05). Conclusion Fuzheng Jianpi traditional Chinese medicine combined with Western medicine in the treatment of children with solid tumors can successfully complete chemotherapy,prolong the survival time, improve the survival rate and improve the quality of life by reducing adverse reactions of chemotherapy.

关 键 词：中西医结合治疗 恶性实体瘤 5年生存率 生存质量 

分 类 号：R73[医药卫生—肿瘤]