Ⅰb2～Ⅱa2期宫颈癌患者术前经动脉介入栓塞化疗的疗效观察  

Clinical Study on Preoperative Transcatheter Arterial Chemoembolization in Patients with Stage Ⅰb2 ～ Ⅱa2 Cervical Cancer

作　　者：陈丰华[1] 吴萍[1] 郑媛[1] 张立晶[1] Chen Fenghua;Wu Ping;Zhen Yuan;Zhang Lijing(Gynecology Clinic,Yiwu Central Hospital,Zhejiang Yiwu 322000,China)

机构地区：[1]义乌市中心医院妇科门诊

出　　处：《中国药师》2019年第7期1300-1302,共3页China Pharmacist

摘　　要：目的:观察术前经动脉介入栓塞化疗对Ⅰb2~Ⅱa2期宫颈癌患者的临床疗效与安全性。方法:Ⅰb2~Ⅱa2期宫颈癌患者85例随机分为A组42例与B组43例。A组术前经动脉介入栓塞化疗,B组术前静脉化疗。两组均采用TP化疗方案:紫杉醇135~175 mg·m-2+顺铂60~75 mg·m-2,持续3周。比较两组治疗疗效、治疗前后血管新生指标变化及药品不良反应发生情况。结果:A组总有效率为80.95%,B组总有效率为74.42%,差异无统计学意义(P>0.05)。两组化疗后血清血管内皮生长因子A(VEGFA)、血管内皮生长因子C(VEGFC)和血管内皮生长因子D(VEGFD)含量均较化疗前降低(P<0.05),且A组均低于B组(P<0.05)。两组药品不良反应差异无统计学意义(P> 0.05)。结论:术前经动脉介入栓塞化疗与静脉化疗对Ⅰb2~Ⅱa2期宫颈癌患者疗效相当,但术前经动脉介入栓塞化疗抑制血管新生效果优于静脉化疗,值得临床借鉴。Objective: To observe the clinical efficacy and safety of preoperative transcatheter arterial chemoembolization in the treatment of Ⅰb2-Ⅱa2 cervical cancer. Methods: Eighty-five patients with stage Ⅰb2-Ⅱa2 cervical cancer were randomly divided into group A( 42 cases) and group B( 43 cases). Group A received preoperative transcatheter arterial chemoembolization and group B received preoperative intravenous chemotherapy. TP regimen was used in both groups: 135-175 mg m-2 paclitaxel + 60-75 mg m-2 cisplatin. Neoadjuvant chemotherapy was performed 2-3 weeks before operation. The therapeutic effect,changes of angiogenesis indices and adverse drug reactions before and after the treatment were compared between the groups. Results: The total effective rate was80.95% in group A and 74.42% in group B without significant difference( P> 0.05). The serum levels of vascular endothelial growth factor A( VEGFA),vascular endothelial growth factor C( VEGFC) and vascular endothelial growth factor D( VEGFD) in both groups were lower than those before the chemotherapy( P<0.05),and those in group A were lower than those in group B( P< 0.05). There was no significant difference in adverse drug reactions between the groups( P>0.05). Conclusion: Preoperative transcatheter arterial chemoembolization is as effective as intravenous chemoembolization in the treatment of stage Ⅰb2-Ⅱa2 cervical cancer,while preoperative transcatheter arterial chemoembolization is superior to intravenous chemoembolization in inhibiting angiogenesis,which is worthy of clinical reference.

关 键 词：术前经动脉介入栓塞化疗 Ⅰb2~Ⅱa2期宫颈癌 疗效 血管内皮生长因子 

分 类 号：R730.53[医药卫生—肿瘤]