生物学导向协调药效和药代的药物设计  

Concise elucidation of coordinating PD and PK based upon biological principles

作　　者：郭宗儒[1] GUO Zong-ru(Institute of Material Medic a,Chinese Academy of Medical Sciencesand Peking Medical College,Beijing 100050,China)

机构地区：[1]中国医学科学院北京协和医学院药物研究所

出　　处：《中国药物化学杂志》2019年第3期167-174,共8页Chinese Journal of Medicinal Chemistry

摘　　要：创新药物的核心是构建融合具有药效药代和安全性的化学结构,将宏观性质和微观结构统一到分子中,前药多以化学原理协调药代和药效间的关系,自21世纪以来更多借助生物学原理形成创制新药的技术和方法,本文从药物化学的视角简析一些平台技术的特征。The core of drug innovation is to construct a chemical structure merging pharmacodynamics(PD),pharmacokinetic(PK)and safe properties,i.e.putting macroscopic property and microscopic structure together in a molecule.Based on chemical principles prodrugs are usually designed to coordinate PD and PK.Since new millennium novel technologies and methods have been established to unify PD and PK according to biological knowledge.This article is to briefly illustrate some features of new technologies from the standpoint of medicinal chemistry.

关 键 词：宏观性质 微观结构 药效学 药代学 靶向载体 

分 类 号：R914[医药卫生—药物化学]