舒更葡糖钠的合成工艺优化  

Optimization in Synthetic Process of Sugammadex Sodium

作　　者：刘月[1] 王娅莉 任风芝[1] 邵昉 程晓昆 李晓露[1] 张雪霞[1] LIU Yue;WANG Yali;REN Fengzhi;SHAO Fang;CHENG Xiaokun;LI Xiaolu;ZHANG Xuexia(National Engineering Research Center of Microbial Medicine,Hebei Industry Microbial Metabolic Engineering & Technology Research Center,State Key Laboratory of Antibody Research & Development,Shijiazhuang 050015,China)

机构地区：[1]微生物药物国家工程研究中心河北省工业微生物代谢工程技术研究中心抗体药物研制国家重点实验室

出　　处：《化学与生物工程》2019年第7期54-58,共5页Chemistry & Bioengineering

摘　　要：以γ-环糊精为起始原料,依次经溴代、硫醚化反应制得舒更葡糖钠粗粉,再进一步精制得到舒更葡糖钠精粉,总收率为71.6%。本合成方法工艺过程简单,能耗低,无污染,操作简单,反应条件温和,收率高,有良好的工业化生产前景。Using γ-cyclodextrin as a raw material,we synthesized Sugammadex sodium crude powder through the steps of bromination and thioetherification.Moreover,we obtained Sugammadex sodium refined powder with the total yield of 71.6% through purification.This process has the advantages of simple process,low energy consumption,non-pollution,simple operation,mild reaction conditions,and high yield,which has a good industrial production prospect.

关 键 词：舒更葡糖钠 Γ-环糊精 制备 纯化 

分 类 号：TQ460.6[化学工程—制药化工] R914.5[医药卫生—药物化学]