美沙拉嗪栓联合自拟解毒凉血汤灌肠治疗直肠型溃疡性结肠炎患者临床疗效  

Mesalazin suppository and enema with self-made Jiedu Liangxue decoction in treatment of rectal ulcerative colitis

作　　者：朱成占[1] 张高伟 张勇 Zhu Chengzhan;Zhang Gaowei;Zhang Yong(Anorectal Department Pingyu County People's Hospital,Zhumadian 463400,China)

机构地区：[1]平舆县人民医院肛肠科,驻马店463400

出　　处：《国际医药卫生导报》2019年第14期2345-2347,共3页International Medicine and Health Guidance News

摘　　要：目的探讨美沙拉嗪栓联合自拟解毒凉血汤灌肠治疗直肠型溃疡性结肠炎患者的临床疗效。方法选取2017年12月至2018年12月本院收治的108例直肠型溃疡性结肠炎患者,随机分为两组,各54例。对照组采用生理盐水灌肠+美沙拉嗪栓治疗,实验组采用自拟解毒凉血汤灌肠+美沙拉嗪栓治疗。治疗1个月,比较两组临床疗效。结果实验组治疗总有效率96.30%,高于对照组81.48%,差异有统计学意义(P<0.05);实验组纤维结肠镜积分、IL-8、TNF-α、血沉、血小板计数分别为(1.0±0.3)分、(71.4±7.9)μg/L、(122.8±20.5)mg/L、(13.5±10.4)mm/h、(220.2±86.7)×10^9,均低于对照组(1.6±0.5)分、(109.1±9.0)μg/L、(148.6±23.3)mg/L、(19.1±12.8)mm/h、(250.5±63.8)×10^9,差异均有统计学意义(均P<0.05);实验组不良反应发生率0.00%,明显低于对照组11.11%,差异有统计学意义(P<0.05)。结论对直肠型溃疡性结肠炎患者给予拟解毒凉血汤灌肠、美沙拉嗪栓联合治疗能有效抑制炎性因子吸收,加速溃疡面愈合,不良反应少,长期用药安全,疗效显著。Objective To investigate the clinical efficacy of mesalazin suppository combined with self-made Jiedu Liangxue decoction in the treatment of ulcerative colitis. Methods 108 patients with rectal ulcerative colitis treated at our hospital from December, 2017 to December, 2018 were randomly divided into an experimental group (n=54) and a control group (n=54). The control group were treated with enema with saline and salazin suppository, and the experimental group with enema with self-made Jiedu Liangxue decoction and mesalazin suppository. After one month’s treatment, the clinical efficacies of the two groups were compared. Results The total effective rate of the experimental group was significantly better than that of the control group (96.30% vs. 81.48%, P < 0.05). The fiberoptic colonoscopy score, IL-8, TNF-α, sedimentation, and platelet count were (1.0±0.3),(71.4±7.9)μg/L,(122.8±20.5)mg/L,(13.5±10.4)mm/h, and (220.2±86.7)×10^9 in the experimental group, and were (1.6±0.5),(109.1±9.0)μg/L,(148.6±23.3)mg/L,(19.1±12.8)mm/h, and (250.5±63.8)×10^9 in the control group (all P < 0.05). The incidence of adverse reactions was significantly lower in the experimental group than in the control group (0.00% vs. 11.11%, P < 0.05). Conclusion Mesalazin suppository and enema with self-made Jiedu Liangxue decoction in the treatment of rectal ulcerative colitis can effectively inhibit the absorption of inflammatory factors and accelerate the healing of ulcerative surface, has fewer adverse reactions, and is safe for a long time, and the curative effect is remarkable.

关 键 词：美沙拉嗪栓 溃疡性结肠炎 直肠型 自拟解毒凉血汤 灌肠 

分 类 号：R574.62[医药卫生—消化系统]