抑郁动物模型研究进展  

Recent progress in research on animal models of depression

作　　者：王文聪 赵雅蔚 何侃[2] WANG Wencong;ZHAO Yawei;HE Kan(School of Clinical Medicine,Jilin University,Changchun 130021,China;Department of Pharmacology,College of Basic Medical Sciences,Jilin University,Changchun 130061)

机构地区：[1]吉林大学临床医学院,长春130021 [2]吉林大学基础医学院药理学系,长春130061

出　　处：《中国比较医学杂志》2019年第7期125-130,共6页Chinese Journal of Comparative Medicine

基　　金：吉林省教育厅“十三五”科学技术项目(JJKH20180246KJ)

摘　　要：抑郁呈现持续性精神低落和情绪障碍,是全世界最常见和最突出的精神障碍之一。合适的抑郁动物模型可以作为有效的手段进行抑郁及相关问题的研究。本文综述了经典的和正在探索的抑郁动物模型造模的实验动物种类、抑郁评价监测指标以及抑郁动物模型。啮齿动物抑郁模型较为成熟,相关研究也较为广泛。非人灵长类动物应用抑郁模型尚在探索,其优势在于与人类亲缘关系近,模拟效果更好。诸多实验作为监测指标各有其适用范畴,应结合研究本身进行选择。成熟的实验动物模型针对不同的研究目的,在行为学水平、内分泌代谢水平、遗传学水平、社会心理水平各有特色,需进行恰当选择。实验动物种类、监测评价指标、抑郁模型造模方法三者密不可分,三者的合理匹配是形成科学有效的抑郁相关动物水平研究的关键。Major depressive disorder is one of the most common and serious mental disorders and is characterized by constant low spirits and emotional disorder.Establishing a suitable animal model of depression will benefit the study of depression-related problems.Here,we have reviewed the animal species,behavioral tests,modelling methods and the underlying mechanisms in most widely used animal models of depression and new models in development.Rodents have been used in depression models for many years.Non-human primate animal models are under research and such animals may have similar behaviors as human beings.Different animal models of depression have similarities and differences in terms of modelled behavior,endocrine and metabolic characteristics,social psychology,and genetics.The characteristics of different models should be considered when choosing one.

关 键 词：抑郁症 动物模型 发病机制 研究进展 

分 类 号：R-33[医药卫生]