实验性高脂血症大鼠模型的建立和评价  

Establishment and evaluation of experimental hyperlipidemia model in rats

作　　者：王俊 孙雅利 房燕娜 陶梦君 袁慧 WANG Jun;SUN Yali;FANG Yanna;TAO Mengjun;YUAN Hui(School of Public Health,Wannan Medical College,Wuhu 241002,China)

机构地区：[1]皖南医学院公共卫生学院

出　　处：《皖南医学院学报》2019年第4期317-319,共3页Journal of Wannan Medical College

基　　金：国家级大学生创新创业训练计划(201810368055);安徽省大学生创新创业训练计划(201710368066)

摘　　要：目的:采用单纯高脂饮食喂养大鼠,评价高脂血症动物模型的效果。方法:将Wistar大鼠随机分为空白对照组和高脂乳剂实验组,每组10只。空白对照组给予普通饲料喂养,高脂乳剂实验组给予高脂乳剂按1 mL/(100 g·d)灌胃,每日给药1次。观察实验期间大鼠的身长、体质量以及Lee′s指数的变化。结果:对照组和实验组大鼠体长和体质量,总体上随着时间的增加而增长,两组大鼠的体质量和体长差异有统计学意义(P<0.05)。两组间Lee′s指数差异具有统计学意义(P<0.05),但随着时间的推移有下降趋势。结论:采用该乳化剂灌胃可促进大鼠体质量增长,能建立较为理想的高脂血症大鼠模型。Objective:To establish and evaluate the experimental model of hyperlipidemia in rats.Methods:Wistar rats were randomly divided into blank control group and experimental group(n=10 for each group).Rats in the blank control group were fed with conventional diet,and those in the experimental group were intragastrically administered with simple high-fat emulsion in dose of 1 mL/100 g,once a day.Changes,including the body length,body weight,and Lee′s index were observed in rats during experiment.Results:Body length and body weight tended to increase with days for rats in the two groups,and the difference was significant between groups(P<0.05).Lee′s index was also different between groups(P<0.05),yet the difference was in downward trend over time.Conclusion:High-fat emulsion via intragastric route can lead to body weight increase in rats,which is an ideal technique for developing experimental animal models of hyperlipidemia.

关 键 词：高脂血症 Lee′s指数 高脂乳剂 

分 类 号：R-332[医药卫生] R589.2