TACE联合放疗对原发性大肝癌患者血清肿瘤标志物及恶性分子表达的影响  

Effect of TACE combined with radiotherapy on expression of serum tumor markers and malignant molecules in patients with primary large liver cancer

作　　者：戴刚毅[1] 张波[2] 何朗 杨雪梅[1] 严沁[1] 徐毅[1] 张盛[1] 熊伟杰[1] 侯赞 DAI Gang-yi;ZHANG Bo;HE Lang;YANG Xue-mei;YAN Qin;XU Yi;ZHANG Shen;XIONG Wei-ji;HOU Zan(Department of Oncology,the Fifth Hospital of Chengdu City,Chengdu 611130,Sichuan,China;Department of Hepatobiliary Surgery,the Fifth Hospital of Chengdu City,Chengdu 611130,Sichuan,China)

机构地区：[1]成都市第五人民医院肿瘤科,四川成都611130 [2]成都市第五人民医院肝胆外科,四川成都611130

出　　处：《海南医学院学报》2019年第14期1074-1077,共4页Journal of Hainan Medical University

基　　金：成都市卫生与健康委员会课题项目(2015194)~~

摘　　要：目的:探讨TACE联合放疗对原发性大肝癌患者血清肿瘤标志物及恶性分子表达的影响。方法:选择在本院进行治疗的原发性大肝癌患者90例,回顾性分析研究对象的治疗方案并分为:接受放疗的对照组51例、接受TACE联合放疗的TACE组39例。对比两组治疗前后血清肿瘤标志物、血管新生指标、凋亡分子表达水平的差异。结果:治疗前,两组血清肿瘤标志物、血管新生指标、凋亡分子表达水平比较,差异无统计学意义(P>0.05)。治疗后,TACE组血清中肿瘤标志物AFP、AFu、CGT、CEA、CA19-9的水平低于对照组;血清中血管新生指标HGF、VEGF、MMP-9、EGFR的水平低于对照组;血清中凋亡分子Bax、Caspase-4、Caspase10的水平高于对照组,Bcl-2、Survivin的水平低于对照组(P<0.05)。结论:原发性大肝癌患者在放疗基础上加入TACE治疗,可进一步降低肿瘤恶性程度。Objective:To investigate the effect of TACE combined with radiotherapy on the expression of serum tumor markers and malignant molecules in patients with primary large liver cancer.Methods:A total of 90 patients with primary large liver cancer who were treated in our hospital between September 2016 and September 2018 were retrospectively analyzed and divided into the control group(n=51)who received radiotherapy and the TACE group(n=39)who received TACE combined with radiotherapy.The expression levels of serum tumor markers,angiogenesis indexes and apoptotic molecules were compared between the two groups before and after treatment.Results:Before treatment,there were no statistically significant differences in the expression levels of serum tumor markers,angiogenesis indexes or apoptotic molecules between the two groups(P>0.05).After treatment,the serum levels of tumor markers AFP,AFu,CGT,CEA and CA19-9 in the TACE group were significantly lower than those in the control group(P<0.05);the serum levels of angiogenesis indexes HGF,VEGF,MMP-9 and EGFR were significantly lower than those in the control group(P<0.05);the serum levels of apoptotic molecules Bax,Caspase-4 and Caspase-10 were significantly higher than those in the control group(P<0.05),while the levels of Bcl-2 and Survivin were significantly lower than those in the control group(P<0.05).Conclusion:TACE on the basis of radiotherapy can further reduce the tumor malignancy in primary large liver cancer patients.

关 键 词：原发性大肝癌 TACE 放疗 肿瘤标志物 恶性分子 

分 类 号：R735.7[医药卫生—肿瘤]