胃癌患者血清中MACC-1抗体和胃泌素G17联合检测及其临床意义  

Combined Detection of MACC-1 Antibody and Gastrin G17 in Serum of Patients with Gastric Cancer and Its Clinical Significance

作　　者：樊华 吕敏[2] 李金田[2] 吴晓柳[2] 朱明[2] 俞军[2] Hua FAN;Min LV;Jintian LI;Xiaoliu WU;Ming ZHU;Jun YU(Editorial Department of Practical Geriatrics,Geriatric Hospital of Nanjing Medical University,Nanjing Jiangsu 210035,China;Molecular Biology Laboratory,Jiangsu Cancer Hospital,Nanjing Jiangsu 210009,China)

机构地区：[1]南京医科大学附属老年医院实用老年医学编辑部,江苏南京210035 [2]江苏省肿瘤医院分子生物室,江苏南京210009

出　　处：《国际感染病学（电子版）》2018年第4期154-155,共2页Infection International(Electronic Edition)

基　　金：江苏省科技厅面上项目BK20161598;江苏省卫健委面上项目H2017035

摘　　要：目的研究胃癌患者血清中MACC-1抗体和胃泌素G17表达。方法采用酶联免疫法(ELISA)检测42例胃癌患者和18例健康志愿者(对照组)血清中MACC-1抗体和胃泌素G17的表达水平,同时评估其临床意义。结果MACC-1和G17表达水平与胃癌患者腺癌组织分化、淋巴转移、PTNM分级有关,胃癌组织中MACC-1和G17表达的相关性呈正相关关系(r=0.466,P<0.05)。结论血清中MACC-1和G17可作为检测胃癌患者微转移的分子标志物。Objective To study the expression of MACC-1 antibody and gastrin G17 in serum of patients with gastric cancer.Methods The expression levels of MACC-1 antibody and gastrin G17 in serum of 42 patients with gastric cancer and 18 healthy volunteers (control group) were detected by enzyme-linked immunosorbent assay (ELISA). The clinical significance was also evaluated.Results The expression levels of MACC-1 and G17 were correlated with adenocarcinoma differentiation,lymphatic metastasis and PTNM grade in gastric cancer patients.There was a positive correlation between the expression of MACC-1 and G17 in gastric cancer tissues (r=0.466,P<0.05).Conclusion Serum MACC-1 and G17 can be used as molecular markers for detecting micrometastasis in gastric cancer patients.

关 键 词：胃癌 MACC-1mRNA 胃泌素G17 酶联免疫法 

分 类 号：R735.2[医药卫生—肿瘤]