手术对非小细胞肺癌患者外周血循环肿瘤细胞的影响  

Effect of surgery on peripheral blood circulating tumor cells in patients with NSCLC

作　　者：郭继华 杨鲲鹏[1] 张进[1] 葛晓晴[1] 侯露[1] Guo Jihua;Yang Kunpeng;Zhang Jin(Department of Thoracic Surgery,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014)

机构地区：[1]郑州大学第二附属医院胸外科

出　　处：《中国现代医药杂志》2019年第7期13-16,共4页Modern Medicine Journal of China

摘　　要：目的探讨非小细胞肺癌(NSCLC)患者经手术治疗后外周血循环肿瘤细胞(CTC)的变化及其临床意义.方法选取我院胸外科2018年1月~2019年1月收治的NSCLC患者58例为研究对象,检测术前、术后1d、术后7d、术后30d的CTC细胞数值,分析手术操作对外周血CTC细胞数值的影响及CTC数值与其他临床资料之间的关系.结果术后1d年龄≥60岁组患者CTC细胞数值高于年龄<60岁组,差异有统计学意义(P<0.05).胸腔镜手术患者术前测量CTC细胞数值低于开胸手术组,差异有统计学意义(P<0.05).病理分期Ⅰ期患者术前及术后1dCTC阳性率均低于其他病理分期患者,差异有统计学意义(P<0.05).患者术后1dCTC细胞数值较术前出现一过性上升,差异有统计学意义(P<0.05).患者术后7dCTC细胞数值较术后1d呈下降趋势,差异有统计学意义(P<0.05).结论手术可导致NSCLC患者外周血CTC细胞出现一过性上升,随后下降.术前CTC与手术方式及病理分期有关,术后1dCTC与年龄及病理分期有关.Objective To investigate the changes and clinical significance of peripheral blood circulating tumor cells in patients with non-small cell lung cancer(NSCLC)after operation.Methods A total of 58 patients with NSCLC who underwent chest surgery in our hospital from Jan 2018 to Jan 2019 were enrolled.The CTC cell values were measured before surgery,1 day after surgery,7 days after surgery,and 30 days after surgery.Analyzed the effect of surgical operations on the value of peripheral blood CTC,and the relationship between CTC values and other clinical data.Results The CTC of patients over 60 years old after operation were higher than those under 60 years old,and the difference was statistically significant(P<0.05).The value of CTC measured before operation in the thoracoscopic surgery group was lower than that in the thoracotomy group(P<0.05).The positive rate of CTC in the pathological stage I patients was lower than that in other pathological stages patients(P<0.05).The number of CTC measured at the first day after surgery was higher than that before operation,and the difference was statistically significant(P<0.05).The value of CTC measured at the seventh day after operation was lower than the first day after operation,and the difference was statistically significant(P<0.05).Conclusion Surgery can lead to a transient increase in peripheral blood CTC in patients with NSCLC,followed by a decrease.Preoperative CTC is associated with surgical methods and pathological staging.CTC at the first day after surgery is associated with age and pathological stage.

关 键 词：非小细胞肺癌 循环肿瘤细胞 手术 

分 类 号：R734.2[医药卫生—肿瘤]