影响鼻咽癌18F-FMISO乏氧显像SUVmax的相关因素初探  

Preliminary exploration of 18F-FMISO PET/CT SUVmax with relevant factors for nasopharyngeal carcinoma

作　　者：吴娜静[1] 徐巧玲[1] 尤徐阳 杨波[3] 蔡炜[4] 陈礼平[1] 张雨[1] 周乐源[3] Wu Najing;Xu Qiaoling;You Xuyang;Yang Bo;Cai Wei;Chen Liping;Zhang Yu;Zhou Leyuan(Department of Nuclear Medicine,Affiliated Hospital of Jiangnan University,the Fourth People′s Hospital of Wuxi,Wuxi 214062,China;Department of Nuclear Medicine,Suzhou Ninth People′s Hospital,Suzhou 215200,China;Department of Radiation Oncology,Affiliated Hospital of Jiangnan University,the Fourth People′s Hospital of Wuxi,Wuxi 214062,China;Department of Radiology,Affiliated Hospital of Jiangnan University,the Fourth People′s Hospital of Wuxi,Wuxi 214062,China)

机构地区：[1]江南大学附属医院、无锡市第四人民医院核医学科,214062 [2]苏州市第九人民医院核医学科,215200 [3]江南大学附属医院、无锡市第四人民医院放疗科,214062 [4]江南大学附属医院、无锡市第四人民医院影像科,214062

出　　处：《中华核医学与分子影像杂志》2019年第7期391-394,共4页Chinese Journal of Nuclear Medicine and Molecular Imaging

摘　　要：目的探讨鼻咽癌原发灶病理类型、分化程度、T分期及肿瘤体积与18F-氟硝基咪唑(FMISO)PET/CT显像最大标准摄取值(SUVmax)的相关性.方法回顾性收集2012年至2015年间行头颈部18F-FMISOPET/CT显像的41例鼻咽癌患者(男31例,年龄18~74岁;女10例,年龄35~67岁)的资料,分析鼻咽癌组织病理类型、分化程度、T分期、肿瘤体积等参数与原发灶SUVmax之间的关系.采用Mann-Whitneyu检验、近似t检验和Spearman相关分析进行统计学处理.结果非角化性癌和鳞状细胞癌原发灶的SUVmax差异无统计学意义(u=183.5,P>0.05),分化型与未分化的鼻咽癌原发灶SUVmax差异也无统计学意义(t'=-1.23,P>0.05);T1~T2期与T3~T4期鼻咽癌原发灶SUVmax分别为1.52±0.43、2.05±0.85,差异有统计学意义(t'=-2.60,P<0.05).SUVmax与肿瘤体积有一定相关性(rs=0.488,P<0.05).结论鼻咽癌原发灶乏氧程度与T分期及肿瘤体积有关,综合分析有助于评估氧负荷及判断预后.Objective To explore the relationship between the maximum standardized uptake value(SUVmax)of 18F-fluoromisonidazole(FMISO)PET/CT and the pathological classification,differentiation,T stage and primary tumor volume of nasopharyngeal carcinoma(NPC).Methods A retrospective analysis was performed on 41 patients with NPC(31 males,age 18-74 years;10 females,age 35-67 years)who underwent head and neck 18F-FMISO PET/CT from 2012 to 2015.The relationship between the clinicopathological parameters(pathological classification,differentiation,T stage,tumor volume)of primary lesion and SUVmax were analyzed.Mann-Whitney u test,approximate t test and Spearman correlation were used for data analysis.Results There was no significant difference in SUVmax between non-keratinizing carcinoma and squamous cell carcinoma(u=183.5,P>0.05),nor between the differentiated carcinoma and undifferentiated carcinoma(t′=-1.23,P>0.05).SUVmax of T1-T2 primary tumor was significantly lower than that of T3-T4 tumor(1.52±0.43 vs 2.05±0.85;t′=-2.60,P<0.05),and SUVmax was correlated with primary tumor volume(rs=0.488,P<0.05).Conclusions The hypoxic degree is related with T stage and primary tumor volume in NPC.The combination analysis of T stage and tumor size will contribute to the assessment of oxygen level and prognosis of primary NPC.

关 键 词：鼻咽肿瘤 细胞低氧 硝基咪唑类 氟放射性同位素 正电子发射断层显像术 体层摄影术 X线计算机 

分 类 号：R739.63[医药卫生—肿瘤]