Polymorphisms in CYP2R1 Gene Associated with Serum Vitamin D Levels and Status in a Chinese Rural Population  

作　　者：WANG Yan HAN Han WANG Jun SHEN Fang YU Fei WANG Ling YU Song Cheng ZHANG Dong Dong SUN Hua Lei XUE Yuan BA Yue WANG Chong Jian LI Wen Jie 

机构地区：[1]Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China [2]Department of Environmental Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China [3]Department of Epidemiological, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China

出　　处：《Biomedical and Environmental Sciences》2019年第7期550-553,共4页生物医学与环境科学（英文版）

基　　金：supported by the National Nature Science Foundation of China [grants number 81872626,81573151,U1204823,and 81573243];Science and Technology Foundation for Innovation Talent of Henan Province [No.154200510010]

摘　　要：Vitamin D, a fat-soluble vitamin and endocrine horm one, and it impacts various bone and extra-bone health, such as osteoporosis, diabetes, and cancer. The main circulating form of vitamin D is 25-hydroxyvitamin D [25(OH)D] and it is a useful clinical biomarker of vitamin D status. The Institute of Medicine (IOM) defines as vitamin D deficiency (VDD) when serum 25(OH)D concentration is less than 20 ng/mL⑴.Worldwide, VDD is recognized as a severe public health problem. In 2007, Holick estimated that globally over one billion people suffered from VDD or vitamin D insufficiency (VDI). In China, it has bee n reported that the prevale nee of VDD ranged from 38.8% to 91.2% in different regions.

关 键 词：POLYMORPHISMS CYP2R1 GENE SERUM VITAMIN D CHINESE RURAL Population 

分 类 号：Q[生物学]