血清甘胆酸对肝病的诊断价值探讨  

Diagnostic Value of Serum Glycocholic Acid for Liver Diseases

作　　者：甘波[1] GAN Bo(Department of Internal Medicine, Baoshan Second People's Hospital, Baoshan, Yunnan Province, 678000 China)

机构地区：[1]保山市第二人民医院内一科

出　　处：《中外医疗》2019年第17期51-53,共3页China & Foreign Medical Treatment

摘　　要：目的探讨血清甘胆酸对肝病的诊断价值。方法于该院2015年11月—2017年11月收治的肝病患者中,随机选取88例作为样本,以疾病类型的不同作为划分依据,将患者分为A组(慢性活动性肝炎)、B组(慢性迁延性肝炎)、C组(肝硬化)、D组(肝癌)4组(每组患者各22例),随机选取该院健康检查的人群22名作为对照组,对比5组患者的血清甘胆酸水平。结果对照组CG(1.50±0.20)mg/L,与A、B、C、D组相比差异有统计学意义(t=5.641、6.900、5.711、6.000,P=0.045、0.032、0.041、0.033)。A组患者CG指标最高,为(22.10±1.25)mg/L。B组CG指标最低,为(7.30±0.15)mg/L。C组及D组CG指标对比,差异无统计学意义(P<0.05)。治疗后,A组CG(2.59±0.58)mg/L、B组CG(1.90±0.10)mg/L、C组CG(2.00±0.13)mg/L、D组CG(1.04±0.05)mg/L,与治疗前相比,数据差异有统计学意义(t=6.008、7.142、6.820、6.775,P<0.05)。结论借助血清甘胆酸诊断肝病,可有效提高疾病检出率,明确疾病类型,为临床对疾病的治疗提供指导。Objective To investigate the diagnostic value of serum glycocholic acid for liver disease. Methods Among the patients with liver disease admitted to our hospital from November 2015 to November 2017, 88 patients were randomly selected as samples. The patients were divided into group A (chronic active hepatitis) and group B (chronic persistent hepatitis), group C (cirrhosis), group D (liver cancer) according to the different types of diseases (22 patients in each group), 22 patients in the hospital were randomly selected as the control group, compared with the serum of 5 groups of patients of glycocholic acid level. Results The control group had CG (1.50±0.20) mg/L, which was statistically significantly different from the A, B, C, and D groups (t=5.641,6.900,5.711,6.000, P=0.045,0.032,0.041,0.033). The CG index was the highest in group A (22.10±1.25) mg/L. The lowest CG index in group B was (7.30±0.15) mg/L. There was no statistically significant difference in the CG index between group C and group D (P<0.05). After treatment, group A CG (2.59±0.58) mg/L, group B CG (1.90±0.10) mg/L, group C CG (2.00±0.13) mg/L, group D CG (1.04±0.05) mg/L. The difference in data was statistically significant (t=6.008,7.142,6.820,6.775, P<0.05). Conclusion The diagnosis of liver disease by serum glycocholic acid can effectively improve the detection rate of diseases, identify the type of disease, and provide guidance for clinical treatment of diseases.

关 键 词：血清甘胆酸 慢性活动性肝炎 慢性迁延性肝炎 肝硬化 肝癌 

分 类 号：R575[医药卫生—消化系统]