比较超声乳化术中林格液和乳酸盐林格液对角膜内皮细胞的影响（英文）  

Comparison of endothelial cell changes by specular microscopy between Ringer’s and Ringer’s lactate during phacoemulsification

作　　者：Eman Desoky Amir Abou Samra Hany Ahmed Helaly Eman Desoky;Amir Abou Samra;Hany Ahmed Helaly(Department of Ophthalmology, Faculty of Medicine, Alexandria University, Alexandria 21259, Egypt)

机构地区：[1]Alexandria大学医学院眼科

出　　处：《国际眼科杂志》2019年第8期1269-1275,共7页International Eye Science

摘　　要：目的:比较林格液和乳酸林格液(RL)在超声乳化术中作为冲洗液的差异,并探讨其对角膜内皮细胞的影响。方法:这是一项前瞻性介入性双盲临床研究,包括100例(100眼)年龄在50~65岁之间的年龄相关性白内障患者。随机分为两组(每组各50眼)。组1使用林格液,组2使用乳酸盐林格液冲洗液。结果:组1患者平均年龄57.5±8岁,组2患者平均年龄58.6±9岁。3mo后,组1内皮细胞密度平均下降8.5%,组2平均下降3.6%(P=0.013)。此外,组1中央角膜厚度平均增加6.9%,组2平均增加1.5%(P=0.006)。通过将测厚仪和高光显微镜参数的变化率与灌水量相关联得出两者间无显著相关性。结论:与乳酸盐林格液相比,使用林格液作为冲洗液可减少术后内皮细胞的损失,也可减轻术后水肿。AIM: To compare the difference between using Ringer s and Ringer s lactate (RL) solutions as irrigating solutions during phacoemulsification and investigate their effect on corneal endothelium. METHODS: This was a prospective interventional double blinded clinical study that included 100 eyes of 100 patients aged between 50 to 65 years suffering from a visually significant age-related cataract and scheduled for routine uncomplicated phacoemulsification. The included eyes were randomly divided into two equal groups (each group included 50 eyes). Group 1 received Ringer s solution and group 2 received Ringer s lactate as an irrigating solution. RESULTS: The first group with Ringer s solution had a mean age of 57.5±8 years and the second group with RL solution had a mean age of 58.6±9 years. After 3mo, endothelial cell density decreased in group 1 by a mean of 8.5%, and in group 2 by a mean of 3.6%( P =0.013). Additionally, central corneal thickness increased in group 1 by a mean of 6.9% and in group 2 by a mean of 1.5%( P = 0.006). By correlating the percentage of change in pachymetry and specular microscopic parameters with volume of irrigation solution used, there was no significant correlation. CONCLUSION: The use of Ringer s lactate as an irrigating solution is associated with less endothelial cell loss postoperatively in comparison to Ringer s solution and also associated with decreased postoperative edema.

关 键 词：林格液 乳酸盐林格液 超声乳化术 角膜水肿 角膜内皮显微镜 

分 类 号：R779.6[医药卫生—眼科]