上皮间充质转化在后囊膜下混浊中的研究进展  

Research progress of epithelial-mesenchymal transformation in posterior subcapsular opacity

作　　者：于童[1] 王静[1,2] 张劲松 Tong Yu;Jing Wang;Jin-Song Zhang(the Key Lenticular Laboratory of Liaoning Province, Shenyang 110005, Liaoning Province, China,the Key Lenticular Laboratory of Liaoning Province, Shenyang 110005, Liaoning Province, China;Shenyang Aier Excellence Eye Hospital, Shenyang 110001, Liaoning Province, China)

机构地区：[1]中国医科大学附属第四医院眼科辽宁省晶状体学重点实验室,中国辽宁省沈阳市110005 [2]沈阳爱尔卓越眼科医院,中国辽宁省沈阳市110001

出　　处：《国际眼科杂志》2019年第8期1309-1312,共4页International Eye Science

基　　金：国家自然科学基金资助项目(No.81870644)~~

摘　　要：白内障是我国首位致盲性眼病,也是世界上多数国家致盲的主要原因,目前手术是唯一有效的治疗方法。而后囊膜下混浊即后发性白内障(PCO)是白内障术后常见的并发症,也是导致术后视力下降的主要原因。研究表明,术后残留的晶状体上皮细胞(LECs)发生上皮间充质转化(EMT)在PCO的发生发展中起到了重要的作用。本文主要概述了近些年来EMT在PCO中的研究进展。Cataract is the first blinding eye disease in China and the main cause of blindness in most countries in the world. Currently, surgery operation is the only effective treatment. Posterior capsular opacification (PCO) is a common complication after cataract surgery, and it is also the crucial induction of vision decline. Studies have shown that epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs) remaining after surgery plays an important role in the occurrence and development of PCO. This article mainly summarizes the research progress of EMT in PCO in recent years.

关 键 词：白内障 上皮间充质转化 后发性白内障 晶状体上皮细胞 

分 类 号：R776.1[医药卫生—眼科]