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作 者:孙亚丽[1] 陈琳[1] SUN Yali;CHEN Lin(Department of Pathology, Shaanxi Provincial People’s Hospital, Xi’an 710068, China)
机构地区:[1]陕西省人民医院病理科
出 处:《临床与病理杂志》2019年第7期1428-1434,共7页Journal of Clinical and Pathological Research
摘 要:目的:观察非小细胞肺癌(non-small cell lung cancer,NSCLC)EB病毒感染与COX-2和P-糖蛋白(p-glycoprotein,P-GP)的相关性.方法:以NSCLC患者72例手术标本为NSCLC组,20例肺良性病变组织为对照组,应用PCR检测2组标本的EB病毒基因组中BamHI-W的部分序列,应用免疫组织化学方法检测2组标本的COX-2和P-GP的表达.结果:NSCLC组COX-2阳性率高于对照组(55.6%vs 15.0%,χ^2=10.342,P=0.001).COX-2阳性者淋巴结转移比例高于阴性者(55.0%vs 28.1%,χ^2=5.237,P=0.022).NSCLC组P-GP阳性率高于对照组(26.4%vs 0%,χ^2=6.651,P=0.010).NSCLC组EB病毒阳性率显著高于对照组(55.6%vs 30.6%,χ^2=9.177,P=0.002).EB病毒阳性者淋巴结转移比例高于阴性者(57.5%vs 25.0%,χ^2=7.659,P=0.006).EB病毒阳性者COX-2的阳性率高于EB病毒阴性者(67.5%vs 40.6%,χ^2=5.200,P=0.023).结论:EB病毒感染对NSCLC的发生、发展的影响可能与COX-2表达相关,但其与肺癌多药耐药无直接相关性.Objective:To observe the correlation of Epstein-Barr virus (EBV) infection and COX-2 and p-glycoprotein (P-GP) in non-small cell lung cancer (NSCLC). Methods:Seventy-two specimens of NSCLC patients were the NSCLC group and 20 specimens of benign lung lesions were the control group. Partial sequence of BamHI-W genome of EB virus was measured by PCR and COX-2 and P-glycoprotein (P-GP) were detected by immunohistochemical methods in the two groups. Results:COX-2 positive rate was higher in NSCLC group than the control group (55.6% vs 15.0%,χ^2=10.342, P=0.001). Compared with the COX-2 negative patients, the COX-2 positive patients had a higher proportion of lymph nodes metastasis (55.0% vs 28.1%,χ^2=5.237, P=0.022). P-GP positive rate was higher in the NSCLC group than the control group (26.4% vs 0%,χ^2=6.651, P=0.010). EB virus-positive rate was significantly higher in the NSCLC group than the control group (55.6% vs 30.6%,χ^2=9.177, P=0.002);compared with EBV negative patients, EBV positive patients had a higher proportion of lymph node metastasis (57.5% vs 25.0%,χ^2=7.659, P=0.006). COX-2 positive rate was higher in the EBV positive patients than the EBV negative patients (67.5% vs 40.6%,χ^2=5.200, P=0.023). Conclusion:The effect of EBV infection on the occurrence and development of NSCLC may be related to the expression of COX-2, but it is not directly related to multidrug resistance of lung cancer.
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