鼻腔冲洗频率对鼻咽癌根治性放疗相关不良反应的临床疗效  

Effect of nasal rinse frequency on adverse reactions associated with radical radiotherapy for nasopharyngeal carcinoma

作　　者：包文庭 邓君健[1] 王庆兰[1] 胡家婷 邓杨清 伍龙[1] 徐细明[1] BAO Wenting;DENG Junjian;WANG Qinglan;HU Jiating;DENG Yangqing;WU Long;XU Ximing(Cancer Center,Renmin Hospital of Wuhan University,Hubei Province,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院肿瘤中心

出　　处：《中国医药导报》2019年第20期112-115,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(81302133)

摘　　要：目的探讨鼻腔冲洗频率对鼻咽癌根治性放疗相关不良反应的临床疗效。方法选取2013年1月~2016年12月于武汉大学人民医院肿瘤科接受鼻咽癌根治性放射治疗患者108例,依照随机数字表法分为A、B两组,均使用鼻可乐冲洗器进行鼻腔冲洗,A组冲洗频率为3次/d,B组冲洗频率为5次/d,冲洗时间为自接受放射治疗之日起至放射治疗结束后1年。记录两组患者黏膜反应、疼痛及焦虑发生率和疗效评价。结果B组患者黏膜反应发生情况明显优于A组,中度及以上疼痛发生率和焦虑评分均低于A组,差异有统计学意义(P<0.05),而两组近期疗效比较差异无统计学意义(P>0.05)。结论接受根治性放疗的鼻咽癌患者进行5次/d鼻腔冲洗较3次/d能进一步减轻局部黏膜不良反应,缓解疼痛及焦虑,提高患者治疗体验及生活质量。Objective To study the therapeutic effect of different nasal flushing frequency on radiotherapy related adverse reactions in patients with nasopharyngeal carcinoma.Methods A total of 108 patients received radical radiotherapy for nasopharyngeal carcinoma in the Oncology Department of Cancer Center,Renmin Hospital of Wuhan University from January 2013 to December 2016 were selected.According to the random number table method,the patients were divided into two groups,group A and group B,who received nasal irrigation with nasal cola irrigator.The frequency of irrigation in group A was 3 times/d,and the frequency of irrigation in group B was 5 times/d,and the irrigation time was from the day of radiotherapy to 1 year after the end of radiotherapy.The incidence and efficacy of mucosal reactions,pain and anxiety in the two groups were recorded.Results The incidence of mucosa reaction in group B was significantly better than that of group A,the incidence of moderate or above degree of pain and anxiety scores were lower than those of group A,the difference was statistically significant (P < 0.05),However,there was no statistically significant difference in the short-term efficacy between the two groups (P > 0.05).Conclusion In patients with nasopharyngeal carcinoma receiving radical radiotherapy,nasal flushing for 5 times/d can further reduce local mucosal adverse reactions,relieve pain and anxiety,and improve patients′ treatment experience and quality of life compared with 3 times/d.

关 键 词：鼻咽癌 鼻腔冲洗 黏膜反应 疼痛程度 焦虑 

分 类 号：R739.63[医药卫生—肿瘤]