扩容治疗对急性缺血性脑卒中患者预后的影响  

The effect of volume expansion therapy on the prognosis of patients with acute ischemic stroke

作　　者：严震行[1] 吴承龙[1] 丁国娟[1] YAN Zhenxing;WU Chenglong;DING Guojuan(Department of Emergency Medicine, Shaoxing People's Hospital in Zhejiang Province, Shaoxing 312000, China)

机构地区：[1]浙江省绍兴市人民医院急诊科

出　　处：《中国现代医生》2019年第19期6-9,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2015ZHB014)

摘　　要：目的分析扩容疗法在急性缺血性脑卒中神经功能预后改善中的应用价值.方法选取2016年1月~2018年2月本院收治的178例急性缺血性脑卒中患者为研究对象,按入院登记薄将患者分为观察组和对照组,每组89例.所有患者均接受急性缺血性脑卒中标准治疗,在此基础上给予对照组氯化钠注射液,观察组应用中分子羟乙基淀粉注射液进行扩容,对比两组及其各亚组相关临床指标.结果两组入院时、出院时、出院3个月及短期和长期神经功能评分比较,差异无统计学意义(P>0.05);观察组大动脉粥样硬化型短期神经功能改善情况优于对照组(P<0.05);观察组低灌注状态者出院时、短期改善、出院3个月、长期改善神经功能均优于对照组低灌注状态者(P<0.05).结论中分子羟乙基淀粉扩容疗法适用于大动脉粥样硬化低灌注型急性缺血性脑卒中患者的临床治疗,有利于改善患者短期和长期神经功能,提高其生活质量.Objective To analyze the application value of volume expansion therapy in the improvement of neurological prognosis in acute ischemic stroke. Methods A total of 178 patients with acute ischemic stroke admitted in our hospital from January 2016 to February 2018 were enrolled. The patients were divided into the observation group and the control group according to the admission register, each of 89 cases. All patients received standard treatment of acute ischemic stroke. On this basis, the control group was given sodium chloride injection. The observation group was treated with molecular hydroxyethyl starch injection for volume expansion. The related indexes between two groups and their subgroups were compared. Results There were no significant differences in the scores of neurological function at admission, discharge, discharge, and short-term and long-term neurological scores between the two groups(P>0.05). The short-term neurological improvement of large atherosclerosis in observation group was better than that of the control group(P<0.05). The improvement of neurological function at discharge, for short term and at three months after discharge, for long term in the observation group was better than that in the control group(P<0.05). Conclusion The medium molecular hydroxyethyl starch volume expansion therapy is suitable for the clinical treatment of acute ischemic stroke patients with aortic atherosclerosis and low perfusion. It is beneficial to improve the short-term and long-term neurological function and improve their quality of life.

关 键 词：扩容疗法 中分子羟乙基淀粉 急性缺血性脑卒中 神经功能 

分 类 号：R743.33[医药卫生—神经病学与精神病学]