早期介入栓塞治疗脑动脉瘤破裂疗效及安全性研究  

Efficacy and safety of early interventional embolization for cerebral aneurysm rupture

作　　者：龙晓东[1] 李爱国[1] 刘之彝[1] 杨与敏[1] LONG Xiaodong;LI Aiguo;LIU Zhiyi(Department of Neurosurgery, Deyang People’s Hospital, Sichuan Province,Deyang 618000)

机构地区：[1]四川省德阳市人民医院神经外科

出　　处：《陕西医学杂志》2019年第8期1000-1002,共3页Shaanxi Medical Journal

基　　金：四川省德阳市科技支撑计划项目(2015SZ021)

摘　　要：目的:观察脑动脉瘤破裂患者早期行介入栓塞术治疗的临床疗效和安全性。方法:选取脑动脉瘤破裂患者120例,均行微弹簧圈介入栓塞治疗,根据患者入院治疗时间的不同,将入院3 d内治疗的72例纳入观察组,将入院3 d后治疗的48例纳入对照组,记录两组患者术后恢复情况,对比两组临床疗效和术后并发症发生情况,并随访观察患者预后情况。结果:观察组术后自主呼吸恢复时间、定向力恢复时间和睁眼时间均较对照组显著缩短(P<0.05);观察组术后完全栓塞率为90.28%,显著高于对照组的52.08%(P<0.05);与对照组相比,观察组术后合并脑血管痉挛、动脉瘤再次破裂、脑积水以及蛛网膜下腔出血发生率均显著降低(P<0.05),且复发率也显著低于对照组(P<0.05);观察组术后6个月的MBI评分显著高于对照组(P<0.05),mRS评分显著低于对照组(P<0.05)。结论:对于脑动脉瘤破裂患者,早期介入栓塞治疗效果显著,可缩短患者术后恢复时间,且术后并发症少,预后好。Objective:To observe the clinical efficacy and safety of early interventional embolization in patients with cerebral aneurysm rupture.Methods:120 patients with cerebral aneurysm rupture who were admitted to were enrolled.All patients underwent micro-coil embolization. According to the time of admission, the 72 patients who were admitted to the hospital within 3 days were included in the observation. In the group, 48 patients who were treated after 3 days of admission were included in the control group.The postoperative recovery of the patients was recorded. The clinical efficacy and postoperative complications of the two groups were compared, and the prognosis of the patients was followed up.Results: The postoperative spontaneous breathing recovery time, orientation recovery time and blink time were significantly shorter in the observation group than in the control group(P<0.05).The complete embolization rate of the observation group was 90.28%,which was significantly higher than that of the control group was 52.08%(P<0.05).Compared with the control group, the incidence of cerebral vasospasm, re-rupture of aneurysm, hydrocephalus and subarachnoid hemorrhage were significantly lower in the observation group(P<0.05), and the recurrence rate was significantly lower than that of the control group(P<0.05);the MBI score of the observation group was significantly higher than that of the control group at 6 months after operation(P<0.05), and the mRS score was significantly lower than that of the control group(P<0.05).Conclusion: For patients with cerebral aneurysm rupture, early interventional embolization has a significant effect, which can shorten the postoperative recovery time, and has fewer postoperative complications and a good prognosis.

关 键 词：脑动脉瘤破裂 治疗 介入栓塞术 早期 微弹簧圈介入 安全性 临床疗效 

分 类 号：R742.9[医药卫生—神经病学与精神病学]