SeDeM Expert System: A review and new perspectives  

作　　者：Mingxian Gu Tianbing Guan Shulin Wan Han Zhang Xuelian Li Songtao Kong Jianbing Ren Huimin Sun Chuanyun Dai 

机构地区：[1]Chongqing University of Science and Technology, Chongqing 401331, China [2]National Institutes for Food and Drug Control, Beijing 100050, China [3]Chongqing LIYUN Nozzle Co., Ltd., Chongqing 401332, China

出　　处：《Journal of Pharmaceutical and Biopharmaceutical Research》2019年第1期36-47,共12页制药与生物制药研究杂志（英文）

摘　　要：The SeDeM Expert System was first known as a galenic pre-formulation system, which was based on the experimental research and quantitative determination of powdered substances. And the mathematical formula provided by the SeDeM Expert System has plays an important role in the study of powder properties. The system can be used not only to evaluate the powder direct compression (DC) of excipients and active pharmaceutical ingredients (API’s), but also to predict the possible formulations, so it can reduce unnecessary research and trials, and shorten the time of development. In this paper, the research development and application of SeDeM Expert System in DC was summarized, and the results showed that with a few exceptions, the system was skilled in predicting acceptable tablet formulations. Finally, the new application prospect of the system is presented, including the application of the Internet traffic and content management (iTCM) database and the new co-processed excipients.

关 键 词：SeDeM EXPERT System radar GRAPH POWDER direct compression pre-formulation coprocessed 

分 类 号：R[医药卫生]