立体定向放疗在结直肠癌肝转移中的应用进展  

Application Progress in Stereotactic Body Radiation Therapy for Colorectal Liver Metastases

作　　者：叶文渊 孙晓南[1] YE Wenyuan;SUN Xiaonan(Department of Radiation Oncology,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou 310016,China)

机构地区：[1]浙江大学医学院附属邵逸夫医院放疗科

出　　处：《医学综述》2019年第14期2716-2720,2725,共6页Medical Recapitulate

基　　金：国家自然科学基金(81672976)

摘　　要：肝脏是结直肠癌最常见的转移部位,立体定向放疗(SBRT)作为非手术局部治疗方式之一,具有精确性高、适形度高、治疗次数少的优点,在肝脏寡转移治疗方面已被广泛应用。近年来随着放疗技术的进步,靶区定位精度不断提高,SBRT在结直肠癌肝转移患者的综合治疗中发挥越来越重要的作用;相关研究也日益增多,在适应人群、剂量和分割方式、临床疗效、安全性及毒副反应、预后因素等方面均积累了一定的研究证据。尽管目前SBRT的治疗策略已初步建立,但仍需要开展更多的前瞻性Ⅲ期研究进一步验证和优化。The liver is the most common metastatic site of colorectal cancer.As one of the non-surgical local treatment methods,stereotactic body radiation therapy(SBRT) has the advantages of high precision,high conformity and few number of sessions,and has been widely used in the treatment of liver oligometastasis.With the advancement of radiotherapy technology in recent years,and the improved locating accuracy of target area,SBRT is playing an increasingly important role in the multimodality treatment of liver metastases from colorectal cancer.The concerning studies are increasing,providing and accumulating research evidence in terms of the applicable population,dose fractionation,clinical efficacy,safety and toxicity ,and the factors influencing prognosis.Although the treatment strategy for SBRT has been initially established,further prospective phase Ⅲ trials for verifying effect and optimization are still needed.

关 键 词：结直肠癌 立体定向放疗 肝转移 

分 类 号：R735.3[医药卫生—肿瘤]