TTF-1和Calretinin在肺腺癌胸水中的表达及意义  

Expression and significance of TTF-1 and Calretinin in pleural fluid of patients with lung adenocarcinoma

作　　者：高福平 魏谨 马平 薛松 GAO Fu-ping;WEI Jin;MA Ping(Department of Pathology,Gaochun People's Hospital,Nanjing 211300,China)

机构地区：[1]江苏省南京市高淳人民医院病理科

出　　处：《吉林医学》2019年第8期1711-1712,共2页Jilin Medical Journal

摘　　要：目的:探讨TTF-1和Calretinin在肺腺癌患者胸水中的诊断价值。方法:利用免疫组化EnVision二步法检测43例肺腺癌患者胸水和45例良性疾病胸水中TTF-1和Calretinin的表达情况。结果:TTF-1在肺腺癌胸水中的阳性表达率为95.35%(41/43),在肺良性疾病胸水中未见阳性表达(0/45),两者TTF-1表达差异有显著统计学意义(P<0.01)。Calretinin在肺腺癌胸水中的阳性表达率为13.95%(6/43),在肺良性疾病胸水中阳性表达率为82.22(37/45),Calretinin在两者中的表达差异有显著统计学意义(P<0.01)。结论:TTF-1和Calretinin可应用于肺腺癌患者胸水中癌细胞的诊断及鉴别诊断。Objective To to investigate the diagnostic value of TTF-1 and Calretinin in pleural effusion of patients with lung adenocarcinoma. Method The expression of TTF-1 and Calretinin in pleural effusion of 43 patients with lung adenocarcinoma and 45 patients with benign diseases was detected by immunohistochemical EnVision two-step method. Results The positive expression rate of TTF-1 in pleural effusion of lung adenocarcinoma was 95.35%(41/43),but not in pleural effusion of benign lung diseases (0/45).There was significant difference in the expression of TTF-1 between the two groups ( P <0.01).The positive expression rate of Calretinin was 13.95%(6/43) in pleural effusion of lung adenocarcinoma and 82.22%(37/45) in pleural effusion of benign lung diseases.There was significant difference in the expression of Calretinin between the two groups ( P <0.01). Conclusion TTF-l and Calretinin are clinically valuable for diagnosing and differentially diagnosing the cancer cells in the pleural fluid of patients with primary lung adenocarcinoma.

关 键 词：肺肿瘤 腺癌 甲状腺转录因子1 钙视网膜蛋白 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]