3-乙基-2-乙酰吡嗪缩4-甲基氨基硫脲Cu(Ⅱ)配合物的合成、结构和DNA结合性质（英文）  

Three Cu(Ⅱ) Complexes with 1-(3-Ethylpyrazin-2-yl)ethylidene)-4-methylthiosemicarbazide: Crystal Structures and DNA-Binding Properties

作　　者：吕目轩 卞琳艳 李梦茹 杨怡 吴伟娜 王元 陈忠 Lü Mu-Xuan;BIAN Lin-Yan;LI Meng-Ru;YANG Yi;WU Wei-Na;WANG Yuan;CHEN Zhong(College of Chemistry and Chemical Engineering,Henan Key Laboratory of Coal GreenConversion,Henan Polytechnic University,Jiaozuo,Henan 454000,China;School of Materials and Mechanical and Electrical Engineering,Jiangxi Science and Technology Normal University,Nanchang 330013,China)

机构地区：[1]河南理工大学化学化工学院,河南省煤炭绿色转化重点实验室,焦作454000 [2]江西科技师范大学材料与机电学院,南昌330013

出　　处：《无机化学学报》2019年第8期1463-1469,共7页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金(No.21001040);河南省自然科学基金(No.182300410183,162300410011);江西省自然科学基金项目(No.20181BAB206011);河南省教育厅高等学校重点科研基金(No.19A150001);江西省教育厅科学技术研究项目(No.GJJ170665);河南理工大学校内基金(No.T2018-3,J2015-4);江西科技师范大学校内基金(No.2015QNBJRC006)资助

摘　　要：合成并通过单晶衍射、元素分析、红外光谱表征了配合物[Cu(L)Br]·DMF (1),[Cu(L)Cl]·2H2O (2)和[Cu2(L)2(SO4)]·H2O·CH3OH (3)的结构(HL为3-乙基-2-乙酰吡嗪缩4-甲基氨基硫脲)。单晶衍射结果表明,配合物1和2中的Cu(Ⅱ)离子与来自1个缩氨基硫脲阴离子配体的N2S给体及1个卤素阴离子配位(1和2中分别为溴离子和氯离子),采取扭曲的平面正方形配位构型。而双核配合物3中,2个Cu(Ⅱ)中心由2个缩氨基硫脲配体的2个硫原子桥联形成Cu2S2簇,Cu…Cu距离为0.318 0 nm。每个Cu(Ⅱ)离子还与来自同一缩氨基硫脲配体的2个氮原子和处于外轴向位置η2-SO4^2-的1个氧原子配位,配位构型为扭曲的四方锥。此外,荧光光谱结果表明,配合物与DNA的相互作用强于配体。Three Cu(Ⅱ) complexes,[Cu(L)Br]·DMF (1),[Cu(L)Cl]·2H2O (2),and [Cu2(L)2(SO4)]·H2O·CH3OH (3)(HL=1-(3-ethylpyrazin-2-yl)ethylidene)-4-methylthiosemicarbazide) have been synthesized and structurally determined by single-crystal X-ray diffraction.The results show that the Cu(Ⅱ) ion in 1 and 2 is surrounded by one anionic thiosemicarbazone ligand with N2S donor set and one halide ion (bromide for 1 and chloride for 2),thus giving a distorted planar square coordination geometry.However,in the dimeric complex 3,two Cu(Ⅱ) ions were doubly bridged by two S atoms of two TSC ligands to form a Cu2S2 core with Cu…Cu distance of 0.318 0 nm.Each of the Cu(Ⅱ) ions is also coordinated by two nitrogen atoms from one TSC ligand and one oxygen atom from the η2-SO4^2- at the outer axial site,with a distorted square pyramid coordination geometry.Moreover,the fluorescence spectra indicate that the interactions of the complexes with DNA are stronger than that of the thiosemicarbazone ligand.CCDC: 1884254,1;1884255,2;1884256,3.

关 键 词：配合物 晶体结构 Cu(Ⅱ) 吡嗪 缩氨基硫脲 DNA结合性质 

分 类 号：O614.121[理学—无机化学]