DC-CIK与化疗、射频消融联用治疗结直肠癌术后肝转移疗效  

Efficacy of DC-CIK combined with chemotherapy and radiofrequency ablation in the treatment of postoperative liver metastasis of colorectal cancer

作　　者：赵海燕[1] 云升[1] 李超 苏乌云[1] 张雪琳 ZHAO Haiyan;YUN Sheng;LI Chao;WU Suyun;ZHANG Xuelin(Department of Oncology, Affiliated Hospital of Neimenggu Medical University, Huhehaote 010050,China;The center of Stem cell, Affiliated Hospital of Neimenggu Medical University, Huhehaote 010050,China)

机构地区：[1]内蒙古医科大学附属医院肿瘤内科 [2]内蒙古医科大学附属医院干细胞中心,内蒙古呼和浩特010050

出　　处：《现代仪器与医疗》2019年第2期57-61,共5页Modern Instruments & Medical Treatment

基　　金：内蒙古医科大学计划百万工程项目，课题编号：YKD2016KJBW008

摘　　要：目的:观察树突状细胞-细胞因子诱导杀伤细胞(DC-CIK)联合化疗、射频消融治疗结直肠癌术后肝转移疗效。方法:回顾性分析我院2012年8月至2015年8月收治的结直肠癌术后肝转移患者临床资料,全身化疗联合射频消融治疗者归入对照组,化疗、射频之外再联合DCCIK治疗者归入观察组,比较两组患者肝转移灶切除率、治疗效果以及治疗前后T细胞亚群变化情况、生存率及生活质量。结果:治疗后观察组肝转移灶切除率24.66%高于对照组的10.67%,差异有统计学意义(P<0.05)。观察组客观控制率(ORR)64.38%高于对照组的29.33%,差异有统计学意义(P<0.05)。治疗前T细胞亚群各指标组间比较差异无统计学意义(P>0.05)。治疗后观察组CD4+与CD4+/CD8+均高于对照组,差异有统计学意义(P<0.05)。治疗后CD8+组间比较差异无统计学意义(P>0.05)。治疗前两组肿瘤标志物水平组间比较差异无统计学意义(P>0.05)。治疗后观察组CEA及CA125水平较对照组低,差异有统计学意义(P<0.05)。观察组1年生存率、2年生存率及3年生存率均高于对照组,差异有统计学意义(P<0.05)。观察组情感功能、生理功能、社会生活与日常生活评分均高于对照组,差异有统计学意义(P<0.05)。结论:常规治疗基础上联合DC-CIK治疗可提高结直肠癌术后肝转移患者免疫功能及肝转移灶切除率,改善生存率及生活质量。Objective: This study aimed to observe the efficacy of dendritic cell-cytokine-induced killers (DC-CIK) combined with chemotherapy and radiofrequency ablation in the treatment of postoperative liver metastasis of colorectal cancer. Methods: The clinical data of the postoperative patients with liver metastases from colorectal cancer admmited in our hospital from August 2012 to August 2015 were retrospectively analyzed, patients treated with systemic chemotherapy combined with radiofrequency ablation were included in the control group, patients treated with DC-CIK in addition to chemotherapy and radiofrequency were included in the observation group, liver metastases resection rate, the effect of treatment and changes of T cell subsets before and after the treatment, survival rate and quality of life were compared between the two groups of patients. Results: After treatment, the resection rate of liver metastasis in the observation group was 24.66% higher than that in the control group (10.67%),and the difference was statistically significant (P<0.05). Objective control rate (ORR) of the observation group was 64.38% higher than that of the control group (29.33%), and the difference was statistically significant (P<0.05). There was no statistically significant difference in T cell subsets between groups before treatment (P>0.05). After treatment, CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group, and the difference was statistically significant (P<0.05). After treatment, there was no significant difference between CD8+ groups (P>0.05). There was no significant difference in the level of tumor markers between the two groups before treatment (P>0.05). After treatment, carcinoembryonic antigen and carbohydrate antigen 125 levels in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). The 1-year survival rate, 2-year survival rate and 3-year survival rate in the observation group were higher than those in the con

关 键 词：结直肠癌 肝转移 树突状细胞 细胞因子诱导的杀伤细胞 化疗 

分 类 号：R735.3[医药卫生—肿瘤]