小剂量阿立哌唑联合氨磺必利治疗首发男性精神分裂症及对泌乳素和糖脂代谢的影响  

Low-dose Aripiprazole combined with Amisulpride in treatment of first-episode male schizophrenia and its effects on prolactin as well as glucose and lipid metabolism

作　　者：沈子童[1] SHEN Zitong(Suzhou City Second People's Hospital,Suzhou 234000 Anhui,China)

机构地区：[1]安徽省宿州市第二人民医院

出　　处：《中国民康医学》2019年第11期74-76,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察氨磺必利联合小剂量阿立哌唑治疗首发男性精神分裂症患者的效果及其对血清泌乳素、血糖、血脂的影响。方法:选取66例首发男性精神分裂症患者作为观察对象,采用随机数字表法将其分为研究组和对照组各33例,研究结束时脱落5例,研究组最终有30例患者,对照组最终有31例患者。对照组给予氨磺必利治疗,观察组在对照组基础上给予小剂量阿立哌唑治疗。采用PANSS量表评价两组治疗前后的精神症状,比较两组治疗前后的血清泌乳素(PRL)、空腹血糖(GLU)、总胆固醇(TC)、高密度脂蛋白(HDL)、三酰甘油(TG)、低密度脂蛋白(LDL)水平。结果:两组在研究前PANSS各分量表得分及总分比较,差异均无统计学意义(P>0.05),在第4周研究组阴性症状评分较对照组显著降低,差异有统计学意义(P<0.05),但治疗结束两组间阴性症状评分比较,差异无统计学意义(P>0.05);治疗4、8周后研究组TC、TG、LDL、PRL水平均低于对照组,HDL高于对照组,差异均有统计学意义(P<0.05);至研究结束研究组PRL水平与基线期比较差异无统计学意义(P>0.05);两组血糖水平与基线期比较差异无统计学意义(P>0.05)。结论:氨磺必利可明显改善首发男性精神分裂症患者的阳性和阴性症状,但有致高泌乳素和高血脂风险,给予小剂量阿立哌唑可以有效改善泌乳素和血脂水平。Objective:To observe effects of Amisulpride combined with low-dose Aripiprazole in treatment of first-episode male schizophrenia and its effects on serum prolactin,blood glucose and blood lipids.Methods:66 male patients with first-episode schizophrenia were selected as the observation subjects.They were divided into study group and control group by using the random number table method,33 cases in each.At the end of the study,5 patients dropped oyt,and the study group eventually had 30 patients,and the control group eventually had 31 patients.The control group was treated with Amisulpride,while the observation group was given low-dose Aripiprazole on the basis of that of the control group.The PANSS scale was used to evaluate the psychiatric symptoms before and after the treatment.The serum prolactin (PRL),fasting blood glucose (GLU),total cholesterol (TC),high-density lipoprotein (HDL),and triglyceride (TG),and low density lipoprotein (LDL) levels were compared between the two groups before and after the treatment.Results:There were no significant differences in the item scores and total scores of PANSS between the two groups before the study (P>0.05).At the 4th week,the negative symptoms scores of the study group were significantly lower than those of the control group,and the differences were statistically significant (P<0.05);however,the difference of the negative symptoms scores between the two groups after the treatment were not statistically significant (P>0.05).4 and 8 weeks after the treatment,the TC,TG,LDL and PRL levels of the study group were lower than those of the control group,the HDL level was higher than that of the control group,and the differences were statistically significant (P<0.05).There was no significant difference in the PRL level of the study group after the treatment and the baseline (P>0.05). There were no significant differences in the blood glucose levels of the two groups after the treatment and the baseline (P>0.05).Conclusions:Amisulpride can significantly improve the positive and

关 键 词：氨磺必利 阿立哌唑 首发男性精神分裂症 泌乳素 糖脂代谢 

分 类 号：R749.3[医药卫生—神经病学与精神病学]