蛛网膜下腔出血病理生理机制研究进展  

Advance in Pathophysiological Mechanism of Subarachnoid Hemorrhage

作　　者：张昌林[1] 倪小佳[1,2,3] 林浩 吴俊标[1,4] 李春花[1] 黎劭学[1,2] 蔡业峰[1,2,3] ZHANG Chang-Lin;NI Xiao-Jia;LIN Hao;WU Jun-Biao;LI Chun-Hua;LI Shao-Xue;CAI Ye-Feng(The Second Clinical School of Guangzhou University of Chinese Medicine,Guangzhou 510120,China;Department of Neurology,Guangdong Provincial Hospital of Chinese Medicine,Guangzhou 510120,China;Research Team on Translational Chinese Medicine for Cerebrovascular Disease,Guangdong Provincial Academy of Chinese Medical Science,Guangzhou 510120,China;Department of Pharmacy,Guangdong Provincial Hospital of Chinese Medicine,Guangzhou 510120,China)

机构地区：[1]广州中医药大学第二临床医学院,广州510120 [2]广东省中医院脑病中心 [3]广东省中医药科学院中医药防治脑血管病转化医学研究团队 [4]广东省中医院药学部

出　　处：《中国卒中杂志》2019年第6期612-618,共7页Chinese Journal of Stroke

基　　金：2016年度广东省中医药局课题（20161097）;广州市科技计划项目（201604020003）;广州中医药大学2017年高水平大学建设（A1-AFD018171Z11096）;广东省中医院院内专项（YN2015BZ05）

摘　　要：蛛网膜下腔出血(subarachnoid hemorrhage,SAH)是临床上常见的脑血管病急危重症,具有高致死率和高致残率的特点。尽管药物和血管内治疗不断进步,SAH患者功能预后的改善仍是目前面临的一大难题。现研究已表明SAH脑血管痉挛,氧化应激反应,炎症反应,血脑屏障破坏与脑水肿,细胞凋亡、焦亡与坏死,细胞自噬,皮质传播抑制和微血栓形成等病理变化过程是影响患者临床转归的潜在机制。本文就SAH病理生理机制进行综述,以期为SAH临床预防、治疗和药物研发提供参考依据。Subarachnoid hemorrhage (SAH) is a common cerebrovascular disease, with a high rate of mortality and disability. Despite many advances in drugs and endovascular treatment, the improvement of clinical prognosis in patients with SAH still faces many challenges. Research has shown that some pathophysiological reaction after SAH can influence the clinical prognosis, these pathophysiological mechanisms includ cerebral vascular spasm, oxidative stress, inflammation, impairment of blood-brain-barrier, brain edema, apoptosis, pyroptosis, necrocytosis and autophagy, cortical spreading depression and microthrombosis and etc. This paper reviewed the recent advance in pathophysiology mechanism in SAH, to provide reference for SAH treatment and drugs research & development.

关 键 词：蛛网膜下腔出血 临床转归 病理生理 

分 类 号：R743.35[医药卫生—神经病学与精神病学]