微粒体在缺血性卒中的作用  

The Role of Microparticles in Ischemic Stroke

作　　者：周蕾 吴冬雨 姚小梅 时彦莹 朱宪策 黄晶[1] 王春雪[1] 张宁[1] ZHOU Lei;WU Dong-Yu;YAO Xiao-Mei;SHI Yan-Ying;ZHU Xian-Ce;HUANG Jing;WANG Chun-Xue;ZHANG Ning(Neuropsychiatry and Clinical Psychology,Department of Neurology,Beijing Tian Tan Hospital,Capital Medical University,Beijing 100070,China;Department of Health Research Methodology Evaluation and Impact,McMaster University,Hamilton L8S4L8,Canada)

机构地区：[1]首都医科大学附属北京天坛医院神经精神医学与临床心理科,北京100070 [2]麦克马斯特大学健康研究方法评估及影响系

出　　处：《中国卒中杂志》2019年第6期619-624,共6页Chinese Journal of Stroke

基　　金：国家重点研发计划（2016YFC1307200）;北京市科委脑计划（Z161100000216131）;215北京市卫生系统高层次卫生技术人才项目（2015-3-038）~~

摘　　要：在血管内皮功能障碍、急慢性血管炎症和高凝状态下均可发现由血小板、白细胞和内皮细胞释放的微粒体.不同种类的微粒体在缺血性卒中病理过程中的作用有所不同:缺血性卒中患者外周血白细胞微粒升高,高水平的白细胞微粒体能加重血管内皮细胞损伤,血浆中长期及高水平的血小板微粒体可诱导微血管血栓形成.另外,不同种类的微粒体均能反映血管内皮损伤的程度,诱导内皮细胞功能失调,加重内皮功能障碍,同时微粒体中携带的信使RNA和微小核糖核酸等能促进内皮细胞增殖,促进动脉粥样硬化斑块内新生血管生成,使斑块更易破裂出血.When there appears vascular endothelial dysfunction, acute and chronic vascular inflammation and hypercoagulation, microparticles (MPs) can be released by platelets, white blood cells and endothelial cells. The roles of different kinds of MPs in the pathological process of ischemic stroke are different: the level of leukocyte-derived MPs (LMPs) is elevated in patients with ischemic stroke, the high level of LMPs can aggravate the injury of vascular endothelial cells and the high level of platelet-derived MPs in plasma for a long time can induce microvascular thrombosis. In addition, different kinds of MPs can reflect the degree of vascular endothelial injury, induce and aggravate endothelial dysfunction. At the same time, mRNA and microribonucleic acid carried in MPs can promote the proliferation of endothelial cells, promote neovascularization in atherosclerotic plaques, and make plaques more prone to rupture and bleeding.

关 键 词：微粒体 缺血性卒中 内皮细胞 血栓形成 

分 类 号：R743.3[医药卫生—神经病学与精神病学]