逆萎促愈汤联合温针灸治疗慢性萎缩性胃炎的临床疗效及对血管内皮因子的影响  

Clinical Effect of Using Niwei Huayu Decoction Combined with Warming Needle Moxibustion in the Treatment of Chronic Atrophic Gastritis and Its Effect on Vascular Endothelial Factors

作　　者：李红君[1] 李文东[1] 陈光华[1] 魏莹[2] 刘福[1] LI Hongjun;LI Wendong;Chen Guanghua(Pharmaceutical Department,the Affiliated Hospital of North Sichuan Medical College (Nanchong Sichuan637000,China))

机构地区：[1]川北医学院附属医院药剂科,四川南充637000 [2]川北医学院药学院药物研究室,四川南充637000

出　　处：《四川中医》2019年第7期119-122,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:观察逆萎促愈汤联合温针灸治疗慢性萎缩性胃炎的临床效果及对血管内皮因子的影响。方法:选择2017年2月~2018年10月我院消化内科收诊的慢性萎缩性胃炎患者90例,根据Excel随机表格法分为对照组和观察组,对照组45例,观察组45例;对照组采用奥美拉唑治疗;观察组在对照组的基础上加用逆萎促愈汤联合温针灸进行治疗。两组患者均治疗8周。对比两组患者治疗疗效、对比两组患者治疗前后血管内皮因子水平、对比两组患者治疗前后萎缩、肠化、异型增生评分、对比两组患者治疗前后中医证候积分。结果:经研究结果显示,观察组总有效率达到94.74%,对照组总有效率达到76.32%,观察组总有效率显著优于对照组(P<0.05)。观察组EGF水平对比低于对照组,VEGF、BFGF水平高于对照组(P<0.05)。观察组萎缩、肠化及异型增生低于对照组(P<0.05)。观察组胃脘灼痛、食欲不振及嗳气反酸积分降低幅度大于对照组(P<0.05)。结论:综上所述,逆萎促愈汤联合温针灸对慢性萎缩性胃炎患者进行治疗,不但发挥了祖国医药的功效,而且还突出了温针灸温经通络的作用。针药并用,疗效叠加。通过改善了患者血管内皮因子的水平,提高了治疗疗效,减轻了临床症状,值得进一步研究推广。Objective: To study the clinical effect of using Niwei Huoyu Decoction combined with warming needle moxibustion in the treatment of chronic atrophic gastritis and its effect on vascular endothelial factors. Methods: Ninety patients with chronic atrophic gastritis were selected from February 2017to October 2018. According to Excel random table method,they were divided into controlled group and observation group,45cases in the controlled group and 45cases in the observation group. The controlled group was treated with omeprazole,and the observation group was treated with Yiwei Quyu Decoction combined with warm acupuncture and moxibustion on the basis of the controlled group. The two groups were treated for 8weeks. The therapeutic effect of the two groups were compared,the levels of vascular endothelial factors before and after treatment were compared,the scores of atrophy,intestinalization and dysplasia before and after treatment were compared,and the scores of TCM syndromes before and after treatment were compared between the two groups. Results: The results showed that the total effective rate of the observation group was 94. 74%,and that of the controlled group was 76. 32%. The total effective rate of the observation group was significantly better than that of the controlled group ( P<0. 05). The level of EGF in the observation group was lower than that in the controlled group,while the levels of VEGF and BFGF in the observation group were higher than those in the controlled group ( P <0. 05). Atrophy,intestinal metaplasia and dysplasia in the observation group were lower than those in the controlled group ( P< 0. 05). The scores of burning pain,loss of appetite and regurgitation of belching in the observation group were significantly lower than those in the controlled group ( P<0. 05). Conclusion: In summary,the treatment of chronic atrophic gastritis patients with Niwei Quyu Decoction combined with warming needle moxibustion not only plays the role of traditional Chinese medicine,but also highlights the role o

关 键 词：逆萎促愈汤 温针灸 慢性萎缩性胃炎的 血管内皮因子 

分 类 号：R573.32[医药卫生—消化系统]