长链非编码RNA在肝癌侵袭转移中的研究进展  

Research progress of long non-coding RNA in the invasion and metastasis of hepatocellular carcinoma

作　　者：蒋志俊 陈洁[1] 黎乐群[1] JIANG Zhi-jun;CHEN Jie(reviewing);LI Le-qun(checking)(Department of Hepatobiliary Surgery,Affiliated Tumor Hospital of Guangxi Medical University/Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research Center,Nanning 530021,Guangxi,China)

机构地区：[1]广西医科大学附属肿瘤医院肝胆外科/广西壮族自治区肿瘤防治研究所

出　　处：《医学研究生学报》2019年第7期765-770,共6页Journal of Medical Postgraduates

基　　金：国家自然科学基金(81502533)

摘　　要：长链非编码RNA(LncRNA)指一类不能编码蛋白质,其长度大于200个核苷酸的RNA分子。研究提示LncRNA通过多种分子机制途径在调控肿瘤生长、侵袭浸润和转移中发挥促进或抑制作用。肝癌术后复发转移是患者低生存率的主要原因,因此系统探讨促进或抑制肝癌侵袭转移的lncRNA的作用机制,有助于肝癌的靶向治疗、预测复发转移和预后判断。文中就LncRNA与肝癌侵袭转移相关机制的最新研究进行综述,以期为肝癌的防治提供新思路。Long non-coding RNA (LncRNA) refers to a class of RNA molecules that are not capable of encoding a protein that is greater than 200 nucleotides in length. It is suggested that LncRNA plays a promoting or inhibiting role in regulating tumor growth, invasion and metastasis through a variety of molecular mechanisms. Primary hepatocellular carcinoma (HCC) is the second leading cause of cancer death in China. Recurrence and metastasis of HCC after operation is the main cause of low survival rate. Therefore, systematically explore the mechanism of lncRNA that promotes or inhibits the invasion and metastasis of HCC, and contributes to the targeted therapy, prediction of recurrence and metastasis and prognosis of HCC. This article reviews the recent research on the mechanism of LncRNA and invasion and metastasis of HCC, in order to provide new ideas for the prevention and treatment of HCC.

关 键 词：原发性肝癌 长链非编码RNA 侵袭 转移 

分 类 号：R735.7[医药卫生—肿瘤]