血凝酶、生长抑素联合奥美拉唑治疗急性上消化道出血的临床疗效评价  

Evaluation on clinical efficacy of hemocoagulase and somatostatin combined with omeprazole in the treatment of acute upper gastrointestinal hemorrhage

作　　者：周秀芬 翟潇路 ZHOU Xiu-fen;DI Xiao-lu(Department of Internal Medicine,Liaocheng Infectious Disease Hospital,Liaocheng 252000,China)

机构地区：[1]聊城市传染病医院内科,252000 [2]聊城市传染病医院护理部,252000

出　　处：《中国实用医药》2019年第20期11-13,共3页China Practical Medicine

摘　　要：目的分析急性上消化道出血采用血凝酶、生长抑素联合奥美拉唑治疗的临床疗效。方法140例急性上消化道出血患者,随机分为对照组与观察组,各70例。对照组采用奥美拉唑治疗,观察组在对照组基础上采用血凝酶与生长抑素治疗,对比两组临床疗效、止血时间、腹痛消失时间、黑便次数、呕血次数、不良反应发生情况。结果观察组显效48例、有效20例、无效2例,临床治疗总有效率为97.14%;对照组显效32例、有效15例、无效23例,临床治疗总有效率为67.14%;观察组临床治疗总有效率高于对照组,差异具有统计学意义(χ2^=21.4748,P<0.05)。观察组止血时间、腹痛消失时间分别为(15.26±0.23)h、(1.23±0.12)d,均短于对照组的(27.86±0.45)h、(2.69±0.45)d,黑便次数、呕血次数分别为(0.82±0.12)、(0.75±0.12)次/d,均少于对照组的(2.18±0.52)、(2.96±0.63)次/d,差异具有统计学意义(t=208.5975、26.2284、21.3215、28.8312,P<0.05)。观察组发生眩晕1例、心悸1例、呕吐1例、恶心1例,不良反应发生率为5.71%;对照组发生眩晕3例、心悸3例、呕吐3例、恶心3例,不良反应发生率为17.14%;观察组不良反应发生率低于对照组,差异具有统计学意义(χ^2=4.5161,P<0.05)。结论急性上消化道出血采用血凝酶、生长抑素联合奥美拉唑治疗,临床疗效显著,能有效止血,改善各种临床症状,且用药安全性高,值得广泛推广。Objective To analyze the clinical efficacy of hemocoagulase and somatostatin combined with omeprazole in the treatment of acute upper gastrointestinal hemorrhage.Methods A total of 140 patients with acute upper gastrointestinal hemorrhage were randomly divided into control group and observation group,with70 cases in each group.The control group was treated with omeprazole,and the observation group was treated with hemocoagulase and somatostatin on the basis of the control group.Comparison were made on clinical efficacy,hemostasis time,disappearance time of abdominal pain,number of black stools,number of hematemesis,and occurrence of adverse reactions between the two groups.Results The observation group had 48 excellent cases,20 effective cases and 2 ineffective cases,with total effective rate of clinical treatment as 97.14%.The control group had 32 excellent cases,15 effective cases and 23 ineffective cases,with total effective rate of clinical treatment as 67.14%.The observation group had higher total effective rate of clinical treatment than the control group,and the difference was statistically significant(χ^2=21.4748,P<0.05).The observation group had shorter hemostasis time,disappearance time of abdominal pain respectively as(15.26±0.23)h and(1.23±0.12)d than(27.86±0.45)h and(2.69±0.45)d in the control group,and less number of black stools,number of hematemesis respectively as(0.82±0.12)and(0.75±0.12)times/d than(2.18±0.52)and(2.96±0.63)times/d in the control group.Their difference was statistically significant(t=208.5975,26.2284,21.3215,28.8312,P<0.05).The observation group had 1 case of vertigo,1 case of palpitations,1 case of vomiting,and 1 case of nausea,with incidence of adverse reactions as 5.71%.The control group had 3 cases of vertigo,3 cases of palpitations,3 cases of vomiting,3 cases of nausea,with incidence of adverse reactions as 17.14%.The observation group had lower incidence of adverse reactions than the control group,and the difference was statistically significant(χ^2=4.5161,P<0.05)

关 键 词：急性上消化道出血 血凝酶 生长抑素 奥美拉唑 联合治疗 临床疗效 

分 类 号：R573.2[医药卫生—消化系统]